Document Detail

Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity.
MedLine Citation:
PMID:  19181487     Owner:  NLM     Status:  MEDLINE    
Activity-based anorexia (ABA) is considered an animal model for anorexia nervosa (AN). By scheduled feeding and voluntary wheel running, it mimics severe body weight loss and increased physical activity in AN. Pharmacological, genetic and imaging studies implicate dopamine and serotonin in the regulation of feeding behavior, food-anticipatory activity, and food reward. Previous studies propose that the nucleus accumbens (NAc) plays an important role in these food-related processes. Here we determined dopamine and serotonin levels in the NAc upon exposure to the ABA model. Surprisingly, the release of dopamine and serotonin in the NAc were not increased during the initiation of food-anticipatory behavior in ABA rats. Dopamine release in the NAc was increased during feeding behavior in ABA rats. During ABA, levels of serotonin were low and circadian activity is blunted. We conclude that during the early stages of development of food-anticipatory activity, increased dopamine does not trigger hyperactivity.
Linda A W Verhagen; Mieneke C M Luijendijk; Gerdien A H Korte-Bouws; S Mechiel Korte; Roger A H Adan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-31
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  19     ISSN:  1873-7862     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  309-16     Citation Subset:  IM    
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience & Pharmacology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Analysis of Variance
Body Temperature / physiology
Body Weight / physiology
Chromatography, High Pressure Liquid / methods
Disease Models, Animal
Dopamine / metabolism*
Eating / psychology
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Hyperkinesis / etiology*,  pathology*
Insulin / blood
Leptin / blood
Microdialysis / methods
Nucleus Accumbens / metabolism*
Radioimmunoassay / methods
Rats, Wistar
Serotonin / metabolism*
Starvation / complications*
Reg. No./Substance:
0/Leptin; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 11061-68-0/Insulin; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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