| Dopamine and schizophrenia: an analysis of the theory. | |
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MedLine Citation:
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PMID: 6145134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The postulated relationship of dopamine to schizophrenia ranks among the most important contemporary theories pertinent to the biological bases of behavior. However, as an examination of the relevant research literature makes clear, the theory has not yet been convincingly validated. This lack of validation is due, in part, to a failure to address the following questions: Is dopamine hyperactivity an etiological and/or a symptom factor in schizophrenia; do laboratory measures used to test the theory truly parallel the relevant clinical phenomena; is attenuated dopamine activity a necessary and/or sufficient condition for remission of schizophrenic symptoms? Analysis of these questions not only provides a departure point for examining the theory, but sets the stage for a reformulation of the theory itself. |
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Authors:
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P L Carlton; P Manowitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neuroscience and biobehavioral reviews Volume: 8 ISSN: 0149-7634 ISO Abbreviation: Neurosci Biobehav Rev Publication Date: 1984 |
Date Detail:
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Created Date: 1984-07-25 Completed Date: 1984-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism Animals Antipsychotic Agents / therapeutic use Behavior, Animal / physiology Brain / physiopathology* Dopamine / physiology* Humans Motor Activity / physiology Prolactin / blood Receptors, Dopamine / drug effects, physiology Schizophrenia / drug therapy, physiopathology* Schizophrenic Psychology |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Receptors, Dopamine; 9002-62-4/Prolactin; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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