Document Detail


Dopamine receptors in rabbit and rat eye: characterization and localization of DA1 and DA2 binding sites.
MedLine Citation:
PMID:  2707038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro autoradiography is used to characterize and localize DA1 and DA2 receptors in rabbit and rat eyes. The bindings of 125I-SCH 23982 (DA1 antagonist) and of 125I-Iodosulpride (DA2 antagonist) to slide mounted tissue sections take place with characteristics expected of substances that recognize DA1 and DA2 receptors respectively. They are saturable, have high affinity and exhibit an appropriate pharmacology. The regional distribution of these receptors indicates that they are mainly present in retina. Precise cellular localizations are visualized in retinal structures by means of histoautoradiography: DA1 receptors are found in inner plexiform layer, outer plexiform layer and inner nuclear layer and DA2 binding sites are present in the two plexiform layers.
Authors:
P P Elena; P Denis; M Kosina-Boix; P Lapalus
Related Documents :
7819528 - Distribution of [3h]alpha,beta-methylene atp binding sites in rat brain and spinal cord.
23598498 - A comparative chemical-biological evaluation of titanium(iv) complexes with a salan or ...
14499328 - Specific in vivo binding to the norepinephrine transporter demonstrated with the pet ra...
6646518 - Light microscopic autoradiographic localization of [3h]arginine-vasopressin binding sit...
23263178 - Bacterial toxin inhibitors based on multivalent scaffolds.
2436668 - Correlations between cyclic amp binding and chemoreception in paramecium.
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Current eye research     Volume:  8     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie, Faculté de Médecine, Nice, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Benzazepines* / analogs & derivatives*,  diagnostic use*
Eye / analysis*
Rabbits
Rats
Receptors, Dopamine / analysis*
Retina / analysis
Sulpiride / analogs & derivatives*,  diagnostic use
Time Factors
Chemical
Reg. No./Substance:
0/8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol; 0/Benzazepines; 0/Receptors, Dopamine; 100038-54-8/iodosulpride; 15676-16-1/Sulpiride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunogold staining of elastin in the wall of the retinal arteries in Macaca mulatta.
Next Document:  Modification and calibration of the Bigliano-Webb Tonometer for improved accuracy of tonometry in ra...