Document Detail


Dopamine receptor subtype 2 expression profile in non-functioning pituitary adenomas and in vivo response to cabergoline therapy.
MedLine Citation:
PMID:  25418156     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To determine the dopamine receptor subtype 2 (DR2) mRNA levels and protein expression and to evaluate the effect of adjuvant cabergoline therapy on tumour volume (TV) in patients with postoperative residual non-functioning pituitary adenoma (NFPA).
METHODS: The mRNA expression was quantified by real time RT-PCR (TaqMan(®) ), and protein expression was evaluated by immunohistochemistry. Tumours were classified according to the percent of immunostained cells for DR2 as scores 1 (<50% of stained cells) or 2 (≥50%). Cabergoline was started at least six months after surgery in nine patients with residual tumours (3 mg/week). The cabergoline effect was prospectively evaluated by magnetic resonance imaging using three-dimensional volume calculation. TV reduction >25% was considered significant.
RESULTS: The DR2 mRNA expression was variable but was observed in 100% of the samples (N=20). DR2 protein expression was also observed in all the tumours (N=34). Twenty-nine tumours (85%) were classified as score 2. The median DR2 mRNA expression was higher in the tumours classified as score 2 compared with score 1 (p=0.007). TV reduction with cabergoline therapy was observed in 67% of the patients (6/9). The median TV before and after six months of treatment was 1.90 cm(3) (0.61-8.74) and 1.69 cm(3) (0.36-4.20) [p=0.02], respectively.
CONCLUSION: In conclusion, DR2 is expressed in all adenomas and the majority of the patients in this study displayed tumour shrinkage on CAB therapy. Thus, CAB might be useful in adjuvant therapy in NFPA patients with residual tumours after surgery. This article is protected by copyright. All rights reserved.
Authors:
Leonardo Vieira Neto; Luiz Eduardo Wildemberg; Aline Barbosa Moraes; Leandro Machado Colli; Leandro Kasuki; Nelma Verônica Marques; Emerson Leandro Gasparetto; Margaret de Castro; Christina Maeda Takiya; Mônica Roberto Gadelha
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-21
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-24     Completed Date:  -     Revised Date:  2014-11-25    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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