Document Detail


Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status.
MedLine Citation:
PMID:  20670471     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Decreased tissue levels of n-3 (omega-3) fatty acids, particularly docosahexaenoic acid (DHA), are implicated in the etiologies of non-puerperal and postpartum depression. This study examined the effects of a diet-induced loss of brain DHA content and concurrent reproductive status on dopaminergic parameters in adult female Long-Evans rats. An alpha-linolenic acid-deficient diet and breeding protocols were used to produce virgin and parous female rats with cortical phospholipid DHA levels 20-22% lower than those fed a control diet containing adequate alpha-linolenic acid. Decreased brain DHA produced a significant main effect of decreased density of ventral striatal D(2)-like receptors. Virgin females with decreased DHA also exhibited higher density of D(1)-like receptors in the caudate nucleus than virgin females with normal DHA. These receptor alterations are similar to those found in several rodent models of depression, and are consistent with the proposed hypodopaminergic basis for anhedonia and motivational deficits in depression.
Authors:
Paul F Davis; Marlies K Ozias; Susan E Carlson; Gregory A Reed; Michelle K Winter; Kenneth E McCarson; Beth Levant
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  13     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-10-25     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  161-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center. Kansas City, Kansas, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basal Ganglia / chemistry
Brain Chemistry / physiology*
Caudate Nucleus / chemistry
Depression, Postpartum / etiology
Diet*
Docosahexaenoic Acids / analysis*
Estradiol / blood
Fatty Acids / analysis
Fatty Acids, Omega-3 / administration & dosage
Female
Male
Parity
Phospholipids / analysis
Postpartum Period
Pregnancy
Rats
Rats, Long-Evans
Receptors, Dopamine / analysis*
Receptors, Dopamine D1 / analysis
Receptors, Dopamine D2 / analysis
Reproduction / physiology*
alpha-Linolenic Acid / administration & dosage
Grant Support
ID/Acronym/Agency:
P20 RR016475/RR/NCRR NIH HHS; P30 HD02528/HD/NICHD NIH HHS; R01 MH071599/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Phospholipids; 0/Receptors, Dopamine; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 50-28-2/Estradiol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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