Document Detail


Dopamine produced from L-DOPA is degraded by endogenous monoamine oxidase in neurons of the dorsal raphe nucleus of the rat: an immunohistochemical study.
MedLine Citation:
PMID:  8813364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study is to examine by immunohistochemistry whether dopamine produced from L-DOPA in serotonin neurons of the rat brain is degraded by endogenous monoamine oxidase (MAO). In rats that received intraperitoneally L-DOPA plus a peripheral decarboxylase inhibitor, carbidopa, a cluster of dopamine-immunoreactive neurons was found in the dorsal raphe nucleus (DR). In L-DOPA/carbidopa-injected rats that were pretreated with an intraperitoneal injection of a MAO inhibitor, pargyline, when compared with the L-DOPA/carbidopa-injected rats without the pargyline pretreatment, neurons of the cluster of the DR became much darker in dopamine staining. The distribution of dopamine-stained neurons in the DR of these rats corresponded very closely to the previously reported distribution of serotonin-immunoreactive neurons of normal rats. In normal or only pargyline-injected rats, dopamine-stained neurons were scarcely observed in the DR. We previously showed that serotonin neurons of the rat DR were induced to contain dopamine by the injection of L-DOPA plus carbidopa. These findings suggest that the newly produced dopamine from L-DOPA in serotonin neurons of the rat DR is degraded by endogenous MAO.
Authors:
R Arai; N Karasawa; I Nagatsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  722     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-18     Completed Date:  1996-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Fujita Health University School of Medicine, Aichi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbidopa / pharmacology
Dopamine / metabolism*
Enzyme Inhibitors / pharmacology
Immunohistochemistry
Levodopa / metabolism*
Male
Monoamine Oxidase / metabolism*
Monoamine Oxidase Inhibitors / pharmacology
Neurons / drug effects,  metabolism*
Pargyline / pharmacology
Raphe Nuclei / drug effects,  metabolism*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Levodopa; 0/Monoamine Oxidase Inhibitors; 38821-49-7/Carbidopa; 555-57-7/Pargyline; EC 1.4.3.4/Monoamine Oxidase

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