| Dopamine produced from L-DOPA is degraded by endogenous monoamine oxidase in neurons of the dorsal raphe nucleus of the rat: an immunohistochemical study. | |
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MedLine Citation:
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PMID: 8813364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study is to examine by immunohistochemistry whether dopamine produced from L-DOPA in serotonin neurons of the rat brain is degraded by endogenous monoamine oxidase (MAO). In rats that received intraperitoneally L-DOPA plus a peripheral decarboxylase inhibitor, carbidopa, a cluster of dopamine-immunoreactive neurons was found in the dorsal raphe nucleus (DR). In L-DOPA/carbidopa-injected rats that were pretreated with an intraperitoneal injection of a MAO inhibitor, pargyline, when compared with the L-DOPA/carbidopa-injected rats without the pargyline pretreatment, neurons of the cluster of the DR became much darker in dopamine staining. The distribution of dopamine-stained neurons in the DR of these rats corresponded very closely to the previously reported distribution of serotonin-immunoreactive neurons of normal rats. In normal or only pargyline-injected rats, dopamine-stained neurons were scarcely observed in the DR. We previously showed that serotonin neurons of the rat DR were induced to contain dopamine by the injection of L-DOPA plus carbidopa. These findings suggest that the newly produced dopamine from L-DOPA in serotonin neurons of the rat DR is degraded by endogenous MAO. |
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Authors:
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R Arai; N Karasawa; I Nagatsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 722 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-12-18 Completed Date: 1996-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Fujita Health University School of Medicine, Aichi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbidopa / pharmacology Dopamine / metabolism* Enzyme Inhibitors / pharmacology Immunohistochemistry Levodopa / metabolism* Male Monoamine Oxidase / metabolism* Monoamine Oxidase Inhibitors / pharmacology Neurons / drug effects, metabolism* Pargyline / pharmacology Raphe Nuclei / drug effects, metabolism* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Levodopa; 0/Monoamine Oxidase Inhibitors; 38821-49-7/Carbidopa; 555-57-7/Pargyline; EC 1.4.3.4/Monoamine Oxidase |
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