Document Detail

Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample.
MedLine Citation:
PMID:  21672565     Owner:  NLM     Status:  MEDLINE    
Depression and variation in dopamine related genes have both independently been associated with food consumption. Depressive symptoms could synergistically interact with genetic variation to influence food intake. We examined the interaction between high depressive symptoms and functional polymorphisms of dopamine transporter (SLC6A3), monoamine oxidase A (MAOA), dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) on intake of high-calorie sweet, high-calorie non-sweet, and low-calorie foods in the National Longitudinal Study of Adolescent Health (Add Health). Multivariate linear regression analyses were used to examine main effects of gene and depression symptoms and their interaction (genotype-by-high depression symptoms) on food categories. Applying a false discovery rate criterion for multiple comparisons indicated a statistically significant interaction for females with high depressive symptoms and the SLC6A3 gene, such that those with the SLC6A3 10/10 allele reported greater intake of high-calorie sweet foods than their counterparts high in depressive symptoms with the SLC6A3 any 9 allele (LS mean 10/10 allele=2.5, SE=.13; LS mean any 9 allele=1.8, SE=.13, p<.05). These findings highlight that the relationship between depression and food intake may vary as a function of genetic polymorphism. Further research is needed to confirm these findings.
Tanya Agurs-Collins; Bernard F Fuemmeler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-06
Journal Detail:
Title:  Appetite     Volume:  57     ISSN:  1095-8304     ISO Abbreviation:  Appetite     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-08-15     Completed Date:  2011-12-16     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-48     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Health Behavior Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd., Rockville, MD 20852, USA.
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MeSH Terms
Depression / genetics*
Dopamine Plasma Membrane Transport Proteins / genetics*,  metabolism
Energy Intake
Food Preferences*
Genetic Predisposition to Disease
Linear Models
Longitudinal Studies
Monoamine Oxidase / genetics,  metabolism
Multivariate Analysis
Polymorphism, Genetic*
Receptors, Dopamine D2 / genetics,  metabolism
Receptors, Dopamine D4 / genetics,  metabolism
Young Adult
Grant Support
Reg. No./Substance:
0/DRD4 protein, human; 0/Dopamine Plasma Membrane Transport Proteins; 0/Receptors, Dopamine D2; 0/SLC6A3 protein, human; 137750-34-6/Receptors, Dopamine D4; EC Oxidase

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