| Dopamine, a neurotransmitter, influences the immune system. | |
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MedLine Citation:
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PMID: 10636479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dopamine (DA) is a monoamine neurotransmitter of both central and peripheral nervous system. Its role in the neural-immune communication has been discussed in the present review. Results reveal that in vivo damage or stimulation of specific central dopaminergic system suppresses or enhances functional activities of the immune effector cells. The possible influences of other immunomodulators of the brain by altering brain DA may be the underlying mechanism. Direct effects of DA on the immune effector cells are also contradictory, it is suppressive in vitro, while in pharmacological doses, it is mostly stimulatory in vivo. The possible mechanisms have been discussed. Lastly, future areas of relevance on DA and immunity have been highlighted to advance our knowledge regarding DA as an immune regulator. |
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Authors:
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S Basu; P S Dasgupta |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 102 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-01-27 Completed Date: 2000-01-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 113-24 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Chittaranjan National Cancer Institute, Calcutta, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation / physiology Brain / physiology Dopamine / physiology* Hematopoiesis Humans Immune System / cytology, physiology* Neurotransmitter Agents / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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