| Dopamine microinjected into brainstem of awake rats affects baseline arterial pressure but not chemoreflex responses. | |
| | |
MedLine Citation:
|
PMID: 20188636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dopamine (DA) is a neuromodulator in the brainstem involved with the generation and modulation of the autonomic and respiratory activities. Here we evaluated the effect of microinjection of DA intracisterna magna (icm) or into the caudal nucleus tractus solitarii (cNTS) on the baseline cardiovascular and respiratory parameters and on the cardiovascular and respiratory responses to chemoreflex activation in awake rats. Guide cannulas were implanted in cisterna magna or cNTS and femoral artery and vein were catheterized. Respiratory frequency (f(R)) was measured by whole-body plethysmography. Chemoreflex was activated with KCN (iv) before and after microinjection of DA icm or into the cNTS bilaterally while mean arterial pressure (MAP), heart rate (HR) and f(R) were recorded. Microinjection of DA icm (n=13), but not into the cNTS (n=8) produced a significant decrease in baseline MAP (-15+/-1 vs 1+/-1mmHg) and HR (-55+/-11 vs -11+/-17bpm) in relation to control (saline with ascorbic acid, n=9) but no significant changes in baseline f(R). Microinjection of DA icm or into the cNTS produced no significant changes in the pressor, bradycardic and tachypneic responses to chemoreflex activation. These data show that a) DA icm affects baseline cardiovascular regulation, but not baseline f(R) and autonomic and respiratory components of chemoreflex and b) DA into the cNTS does not affect either the autonomic activity to the cardiovascular system or the autonomic and respiratory responses of chemoreflex activation. |
| | |
Authors:
|
Waldyr M Oliva; Erica M Granjeiro; Leni G H Bongamba; Ricardo A Mendes; Benedito H Machado |
Related Documents
:
|
12504916 - Central serotonin4 receptors selectively regulate the impulse-dependent exocytosis of d... 1654866 - Changes in brain dopamine levels, oocyte growth and spermatogenesis in rainbow trout, o... 9802826 - Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained p... 9694936 - Nucleus accumbens dopaminergic medication of fixed interval schedule-controlled behavio... 7853866 - Reinforcement effects of boschniakia rossica on discrimination learning in cholinergic ... 8757376 - Stimulation of pancreatic growth. distal small bowel resection mediated by increased le... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-26 |
Journal Detail:
|
Title: Autonomic neuroscience : basic & clinical Volume: 155 ISSN: 1872-7484 ISO Abbreviation: Auton Neurosci Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-31 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 73-81 Citation Subset: IM |
Affiliation:
|
Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects*, physiology Brain Stem / drug effects*, metabolism Chemoreceptor Cells / drug effects* Consciousness Dopamine / administration & dosage*, metabolism Enzyme Inhibitors / pharmacology Heart Rate / drug effects*, physiology Male Microinjections Plethysmography, Whole Body Potassium Cyanide / pharmacology Rats Rats, Wistar Respiratory Rate / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 151-50-8/Potassium Cyanide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Deliberative assessment of surrogate consent in dementia research.
Next Document: Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1.