Document Detail

Dopamine mediation of the feeding response to violations of spatial and temporal expectancies.
MedLine Citation:
PMID:  11334649     Owner:  NLM     Status:  MEDLINE    
The present studies were aimed at further characterizing the role of DA in motivation. Rats, conditioned to expect food in one environment and no food in another, all received food on the test night. Those in the environment in which food was unexpected ate four times as much as those eating where food was expected. The overeating was eliminated by administration of the D2 antagonist raclopride. Another expectancy, timing of light offset in rats entrained to a fixed light--dark cycle, was violated by unexpectedly turning the lights off 1 h early. This provoked an elevation in food intake, which was also eliminated by the administration of raclopride. Feeding in two other situations not involving violation of expectancies (food deprivation; normal light offset) was unaffected by DA antagonism. These findings support the idea that DA signals errors in expectancy and that DA signaling is necessary for certain behavioral responses to unexpected events.
M F Roitman; G van Dijk; T E Thiele; I L Bernstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioural brain research     Volume:  122     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-05-03     Completed Date:  2001-10-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM    
Program in Neurobiology and Behavior, University of Washington, Box 351525, Guthrie Hall, Seattle, WA 98195, USA.
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MeSH Terms
Dopamine / physiology*
Dopamine Antagonists / pharmacology
Eating / drug effects
Feeding Behavior / drug effects,  physiology*
Food Deprivation
Nucleus Accumbens / physiology
Raclopride / pharmacology
Rats, Long-Evans
Receptors, Dopamine D2 / antagonists & inhibitors
Space Perception / drug effects,  physiology*
Time Perception / drug effects,  physiology*
Grant Support
Reg. No./Substance:
0/Dopamine Antagonists; 0/Receptors, Dopamine D2; 84225-95-6/Raclopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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