Document Detail

Dopamine and mania. The effects of trans- and cis-clopenthixol in a double-blind pilot study.
MedLine Citation:
PMID:  6222099     Owner:  NLM     Status:  MEDLINE    
Sordinol is composed of the mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-clopenthixol does not. Sordinol-depot contains the almost pure cis-clopenthixol and appears to be less sedating than the oral and short-lasting intramuscular administration forms. In a double-blind pilot study with 10 manic patients, trans-clopenthixol was compared with cis-clopenthixol. Although not reaching statistical significance, cis-clopenthixol showed anti-manic effects, while trans-clopenthixol remained ineffective. It is concluded that the anti-dopaminergic effect of cis-clopenthixol is essential for its anti-manic effect, which is in agreement with the hypothesis of involvement of the dopaminergic system in the pathogenesis of mania.
W A Nolen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of affective disorders     Volume:  5     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
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MeSH Terms
Affective Disorders, Psychotic / drug therapy*
Bipolar Disorder / drug therapy*,  psychology
Clopenthixol / therapeutic use*
Dose-Response Relationship, Drug
Double-Blind Method
Psychiatric Status Rating Scales
Receptors, Dopamine / drug effects*
Thioxanthenes / therapeutic use*
Reg. No./Substance:
0/Receptors, Dopamine; 0/Thioxanthenes; 982-24-1/Clopenthixol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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