| Dopamine infusion for post-resuscitation blood pressure support after profound asphyxia in near-term fetal sheep. | |
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MedLine Citation:
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PMID: 23104935 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dopamine is commonly used for blood pressure support in the neonate, but has limited empirical evidence to support its use. We tested the hypothesis that after near-terminal asphyxia in utero, dopamine infusions would prevent secondary hypotension. Fetal sheep (122-129 days of gestation, term is 147 days) received umbilical cord occlusion for 15 min or sham occlusion (n=5). If MAP fell below 90% of baseline within 6 h after occlusion fetuses were randomized to either dopamine infusion starting at 4 μg/kg/min and titrated according to MAP up to a maximum of 40 μg/kg/min (n=5) or to the same volume of normal saline (n=5). Dopamine infusion, initiated at a median of 180 min (range 96-280), was associated with a marked, but transient increase in MAP and fall in femoral blood flow compared to saline. Terminal hypotension developed later in the 4/5 fetuses who received maximum dopamine infusions than in 5/5 receiving saline infusion (517 min (240-715) vs 106 min (23-497) after the start of infusions, p<0.05). In conclusion dopamine infusion delayed but did not prevent terminal hypotension after severe asphyxia. |
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Authors:
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Paul P Drury; Lindsea C Booth; Laura Bennet; Joanne O Davidson; Bert Wibbens; Alistair Jan Gunn |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-26 |
Journal Detail:
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Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: Exp. Physiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 University of Auckland; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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