Document Detail

Dopamine infusion for post-resuscitation blood pressure support after profound asphyxia in near-term fetal sheep.
MedLine Citation:
PMID:  23104935     Owner:  NLM     Status:  Publisher    
Dopamine is commonly used for blood pressure support in the neonate, but has limited empirical evidence to support its use. We tested the hypothesis that after near-terminal asphyxia in utero, dopamine infusions would prevent secondary hypotension. Fetal sheep (122-129 days of gestation, term is 147 days) received umbilical cord occlusion for 15 min or sham occlusion (n=5). If MAP fell below 90% of baseline within 6 h after occlusion fetuses were randomized to either dopamine infusion starting at 4 μg/kg/min and titrated according to MAP up to a maximum of 40 μg/kg/min (n=5) or to the same volume of normal saline (n=5). Dopamine infusion, initiated at a median of 180 min (range 96-280), was associated with a marked, but transient increase in MAP and fall in femoral blood flow compared to saline. Terminal hypotension developed later in the 4/5 fetuses who received maximum dopamine infusions than in 5/5 receiving saline infusion (517 min (240-715) vs 106 min (23-497) after the start of infusions, p<0.05). In conclusion dopamine infusion delayed but did not prevent terminal hypotension after severe asphyxia.
Paul P Drury; Lindsea C Booth; Laura Bennet; Joanne O Davidson; Bert Wibbens; Alistair Jan Gunn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-26
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 University of Auckland;
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