Document Detail


Dopamine formation from phenylalanine: independent existence in caudate nucleus synaptosomes.
MedLine Citation:
PMID:  915502     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dopa and dopamine formations from phenylalanine and tyrosine in rat caudate nucleus synaptosomal preparation were studied. Phenylalanine and tyrosine, labelled with either 14C or 3H, were employed as cosubstrates leading to the formations of double labelled Dopa and dopamine. The ratio of the two isotopes in dopamine was found to be significantly different from that in Dopa. The results suggest that Dopa formed from the cosubstrates are compartmented.
Authors:
S P Bagchi; T M Smith
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of neural transmission     Volume:  41     ISSN:  0300-9564     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1977  
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Caudate Nucleus / metabolism*
Dihydroxyphenylalanine / biosynthesis
Dopamine / biosynthesis*
Female
Phenylalanine / metabolism*
Rats
Synaptosomes / metabolism*
Tyrosine / metabolism
Chemical
Reg. No./Substance:
55520-40-6/Tyrosine; 63-84-3/Dihydroxyphenylalanine; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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