Document Detail

Dopamine and food reward: effects of acute tyrosine/phenylalanine depletion on appetite.
MedLine Citation:
PMID:  22230253     Owner:  NLM     Status:  MEDLINE    
It has been suggested that obese individuals over-eat in order to compensate for deficits in the dopaminergic reward system. The current study used acute tyrosine/phenylalanine depletion (ATPD) to investigate the effect of reduced dopamine function on appetite and the reward value of food in healthy volunteers. The compensatory-eating hypothesis would predict an increase in the reward value and consumption of food following depletion by this method. In a double-blind, counterbalanced, crossover study, 17 male participants (mean age=29.2 (SEM=2.7) years; mean body mass index=24.4 (SEM=0.6) kg/m(2)) were administered with a tyrosine/phenylalanine-free mixture (TYR/PHE-free; depletion condition) and a balanced amino acid mixture (BAL; control). Plasma amino acid levels were measured at baseline and peak depletion (300 min). Appetite, willingness to pay for food, liking, desired portion size and ad libitum food intake were also assessed. The TYR/PHE-free mixture was associated with significant decreases in tyrosine, phenylalanine, and the ratio of tyrosine+phenylalanine to the other large neutral amino acids (all p<.001). There were no effects on our measures of willingness to pay for food or liking. However, in the TYR/PHE-free condition, participants reported significantly lower levels of hunger following a fixed-test meal relative to the BAL condition. In conclusion, we found no evidence for compensatory eating following ATPD. Our results also provide support for the role of dopamine in motivational components of eating.
Charlotte A Hardman; Vanessa M B Herbert; Jeffrey M Brunstrom; Marcus R Munafò; Peter J Rogers
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Publication Detail:
Type:  Journal Article     Date:  2011-12-30
Journal Detail:
Title:  Physiology & behavior     Volume:  105     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-08-15     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1202-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Analysis of Variance
Appetite Regulation / physiology*
Cross-Over Studies
Dopamine / deficiency,  physiology*
Double-Blind Method
Eating / physiology,  psychology
Hunger / physiology
Motivation / physiology*
Phenylalanine / blood,  deficiency*
Reference Values
Tyrosine / blood,  deficiency*
Reg. No./Substance:
42HK56048U/Tyrosine; 47E5O17Y3R/Phenylalanine; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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