Document Detail

Dopamine does not enhance furosemide-induced natriuresis in patients with congestive heart failure.
MedLine Citation:
PMID:  8829118     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine whether the addition of low-dose (renal-dose) dopamine to furosemide therapy enhances natriuresis in patients with compensated congestive heart failure, New York Heart Association Class II or III. We performed a randomized, controlled, open-label, crossover study wherein urinary sodium, creatinine, and furosemide excretion rates and GFR determined by inulin clearance rates were measured during each of three treatment interventions: furosemide infusion alone, dopamine infusion alone, and furosemide and dopamine infusions administered concurrently. Six of eight recruited subjects (4 male, 2 female) were able to complete the study. The baseline sodium excretion rate after equilibration on a metabolic diet was 6.7 +/- 0.7 mEq (mean +/- SE) over 3 h. Infusion of dopamine alone caused a slight nonsignificant increase in natriuresis to 36.7 +/- 8.5 mEq/3 h. Furosemide alone markedly increased sodium excretion to 276.6 +/- 47.2 mEq/3 h. No significant additional increment in natriuresis occurred when dopamine and furosemide were administered concurrently (253.8 +/- 73.6 mEq/3 h). Neither dopamine, furosemide, or their coadministration affected GFR. In conclusion, infusion of low-dose dopamine does not enhance furosemide-induced urinary sodium excretion rates in patients with compensated congestive heart failure, New York Heart Association Class II or III.
D L Vargo; D C Brater; D W Rudy; S K Swan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  7     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-03-05     Completed Date:  1997-03-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1032-7     Citation Subset:  IM    
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA.
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MeSH Terms
Diuretics / pharmacology*,  therapeutic use
Dopamine / pharmacology*,  therapeutic use
Drug Interactions
Furosemide / pharmacology*,  therapeutic use
Glomerular Filtration Rate / drug effects
Heart Failure / drug therapy*,  etiology,  physiopathology
Middle Aged
Natriuresis / drug effects*
Prospective Studies
Sodium Chloride, Dietary / administration & dosage
Treatment Outcome
Ventricular Dysfunction, Left / complications
Grant Support
M01 R00750//PHS HHS; R01 AG07631/AG/NIA NIH HHS; R01 DK 37994/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Diuretics; 0/Sodium Chloride, Dietary; 54-31-9/Furosemide

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