Document Detail

Dopamine depresses minute ventilation in patients with heart failure.
MedLine Citation:
PMID:  9679718     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low-dose dopamine is frequently used in patients in the intensive care setting. Dopamine may inhibit chemoreceptor afferents and hence decrease chemoreflex sensitivity to hypoxia. METHODS AND RESULTS: In a double-blind, randomized, crossover study, we determined the effects of dopamine (5 microg x kg(-1) x min(-1)) and placebo infusion on oxygen saturation, minute ventilation, and sympathetic nerve activity during normoxia and 5 minutes of hypoxia in 10 normal young subjects. We further investigated the effects of dopamine and placebo on minute ventilation during normoxic breathing in 8 patients with severe heart failure and in 8 age-matched control subjects. Dopamine did not decrease minute ventilation during normoxia in normal subjects. During hypoxia, minute ventilation was 12.9+/-1.3 L/min on dopamine and 15.8+/-1.5 L/min on placebo (P<0.0001). Oxygen saturation during hypoxia was lower with dopamine (78+/-3%) than placebo (84+/-2%; P<0.0001). Sympathetic nerve activity during hypoxia was not enhanced with dopamine despite the lower O2 saturation. Subjects were able to maintain a voluntary apnea to a lower oxygen saturation on dopamine than on placebo (P<0.05). In heart failure patients breathing room air, but not in age-matched control subjects, dopamine decreased minute ventilation despite decreased oxygen saturation and increased PETCO2 during dopamine (all P< or =0.02). CONCLUSIONS: Dopamine inhibits chemoreflex responses during hypoxic breathing in normal humans, preferentially affecting the ventilatory response more than the sympathetic response. Dopamine also depresses ventilation in normoxic heart failure patients breathing room air. Ventilatory inhibition by low-dose dopamine may adversely influence outcome in hypoxic patients, especially in patients with heart failure.
P van de Borne; R Oren; V K Somers
Related Documents :
2579578 - Effect of hypoxia on feline intestinal capillary permeability.
2240778 - Postadulticide pulmonary hypertension of canine heartworm disease: successful treatment...
3198758 - Hypoxia-induced increases in pulmonary transvascular protein escape in rats. modulation...
24984178 - The effect of a single nucleotide polymorphism of the cyp4f2 gene on blood pressure and...
18511358 - Polypropylene mesh covered colonic anastomosis. results of a new anastomosis technique.
699258 - Arterial insufficiency of the hand evaluated by digital blood pressure and arteriograph...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  98     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-13     Completed Date:  1998-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  126-31     Citation Subset:  AIM; IM    
Department of Internal Medicine and the Cardiovascular Center, University of Iowa Hospitals and Clinics, Iowa City, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / drug therapy,  physiopathology
Cardiac Output, Low / drug therapy*,  physiopathology*
Cross-Over Studies
Dopamine / administration & dosage,  therapeutic use*
Dose-Response Relationship, Drug
Double-Blind Method
Reference Values
Respiration / drug effects*
Grant Support
Comment In:
Circulation. 1998 Jul 14;98(2):97-9   [PMID:  9679713 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of long-term smoking on myocardial blood flow, coronary vasomotion, and vasodilator capacity...
Next Document:  Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-sta...