| Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. | |
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MedLine Citation:
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PMID: 8548806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice unable to synthesize dopamine (DA) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in noradrenergic cells. These DA-deficient (DA-/-) mice were born at expected frequency but became hypoactive and stopped feeding a few weeks after birth. Midbrain dopaminergic neurons, their projections, and most characteristics of their target neurons in the striatum appeared normal. Within a few minutes of being injected with L-dihdroxyphenylalanine (L-DOPA), the product of TH, the DA-/- mice became more active and consumed more food than control mice. With continued administration of L-DOPA, nearly normal growth was achieved. These studies indicate that DA is essential for movement and feeding, but is not required for the development of neural circuits that control these behaviors. |
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Authors:
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Q Y Zhou; R D Palmiter |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 83 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-02-21 Completed Date: 1996-02-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1197-209 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195-7370, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Fibers
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metabolism Animals Animals, Newborn Behavior, Animal / physiology* Dopamine / analysis, deficiency* Dopamine beta-Hydroxylase / metabolism Drinking Behavior / physiology* Dynorphins / biosynthesis Embryo, Mammalian / physiology Feeding Behavior / physiology* Immunohistochemistry In Situ Hybridization Levodopa / pharmacology Mesencephalon / enzymology Mice Mice, Transgenic Mutation / physiology Neostriatum / cytology, metabolism Neurons / chemistry, cytology, physiology Norepinephrine / biosynthesis, deficiency Substance P / biosynthesis Transgenes / physiology Tyrosine 3-Monooxygenase / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD-09172/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 33507-63-0/Substance P; 51-41-2/Norepinephrine; 74913-18-1/Dynorphins; EC 1.14.16.2/Tyrosine 3-Monooxygenase; EC 1.14.17.1/Dopamine beta-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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