Document Detail

Dopamine d1 and d2 receptor antagonism in the preoptic area produces different effects on maternal behavior in lactating rats.
MedLine Citation:
PMID:  16187835     Owner:  NLM     Status:  MEDLINE    
The preoptic area (POA) is critical for maternal behavior in rats but little is known about what neurotransmitters released here influence maternal responding. POA infusion of 10 microg (but not 2 microg) of the dopamine D1 receptor antagonist SCH-23390 greatly impaired retrieval and licking of pups but not other maternal or nonmaternal behaviors in lactating rats. In contrast, POA infusion of 10 microg (but not 2 microg) of the D2 receptor antagonist raclopride facilitated nursing but did not affect oral maternal behaviors. SCH-23390 in the medial hypothalamus tended to impair licking but not retrieval. Raclopride in the medial hypothalamus had no effects. Therefore, D1 and D2 receptor activity, particularly in the POA, is important for regulating different maternal behaviors.
Stephanie M Miller; Joseph S Lonstein
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  119     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2006-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1072-83     Citation Subset:  IM    
Copyright Information:
(c) 2005 APA
Department of Psychology, Michigan State University, East Lansing, MI 48824, USA.
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MeSH Terms
Analysis of Variance
Behavior, Animal / drug effects
Benzazepines / pharmacology*
Dopamine Antagonists / pharmacology*
Dose-Response Relationship, Drug
Lactation / drug effects*
Maternal Behavior / drug effects*
Preoptic Area / drug effects*
Raclopride / pharmacology*
Rats, Long-Evans
Reaction Time / drug effects
Time Factors
Grant Support
Reg. No./Substance:
0/Benzazepines; 0/Dopamine Antagonists; 84225-95-6/Raclopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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