Document Detail


Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism.
MedLine Citation:
PMID:  12604788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in the firing pattern of midbrain dopamine neurons are thought to encode information for certain types of reward-related learning. In particular, the burst pattern of firing is predicted to result in more efficient dopamine release at target loci, which could underlie changes in synaptic plasticity. In this study, the effects of dopamine on the firing patterns of dopaminergic neurons in vivo and their electrophysiological characteristics in vitro were examined by using a genetic dopamine-deficient (DD) mouse model. Extracellular recordings in vivo showed that, although the firing pattern of dopamine neurons in normal mice included bursting activity, DD mice recordings showed only a single-spike pattern of activity with no bursts. Bursting was restored in DD mice after systemic administration of the dopamine precursor, L-3,4-dihydroxyphenylalanine (L-dopa). Whole-cell recordings in vitro demonstrated that the basic electrophysiology and pharmacology of dopamine neurons were identical between DD and control mice, except that amphetamine did not elicit a hyperpolarizing current in slices from DD mice. These data suggest that endogenously released dopamine plays a critical role in the afferent control of dopamine neuron bursting activity and that this control is exerted via a network feedback mechanism.
Authors:
Carlos A Paladini; Siobhan Robinson; Hitoshi Morikawa; John T Williams; Richard D Palmiter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-02-25
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  100     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-05     Completed Date:  2003-05-13     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2866-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amphetamine / pharmacology
Amphetamines / metabolism,  pharmacology
Animals
Cell Membrane / physiology
Dopamine / metabolism,  pharmacology*
Dopamine Agonists / pharmacology
Dose-Response Relationship, Drug
Electrophysiology
Levodopa / pharmacology
Mice
Mice, Inbred C57BL
Neurons / metabolism*
Quinpirole / pharmacology
Time Factors
gamma-Aminobutyric Acid / pharmacology
Grant Support
ID/Acronym/Agency:
DA04523/DA/NIDA NIH HHS; R01 DA015687/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Amphetamines; 0/Dopamine Agonists; 20OP60125T/Quinpirole; 46627O600J/Levodopa; 56-12-2/gamma-Aminobutyric Acid; CK833KGX7E/Amphetamine; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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