Document Detail

Dopamine-beta-hydroxylase in patients with cystic fibrosis.
MedLine Citation:
PMID:  3732334     Owner:  NLM     Status:  MEDLINE    
The enzymatic activity of plasma dopamine-beta-hydroxylase (DBH) was determined in 92 children/adolescents with cystic fibrosis, in 25 parents (heterozygotes) of these patients and in 68 healthy controls. Statistically significant (P less than 0.01) lower DBH levels were found in cystic fibrosis patients (17.9 +/- 1.4 mumol/min per 1, SEM) compared to the controls (25.5 +/- 2.1 mumol/min per 1). In 37 patients plasma norepinephrine and dopamine levels were compared to the enzymatic activity, no significant correlation between these variables being shown (r = -0.134 for norepinephrine; r = 0.159 for dopamine). However, due to the large variability of DBH within the groups and due to the lack of relationship of this enzymatic activity to plasma catecholamines, it is concluded that these differences may neither account for the observed elevation of plasma dopamine in cystic fibrosis patients (0.94-6.73 nmol/l vs. 0.01-0.986 nmol/l for controls) nor for their putative autonomic dysfunction.
M H Schöni; K Türler; H Käser; R Kraemer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pediatrics     Volume:  145     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  80-3     Citation Subset:  IM    
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MeSH Terms
Age Factors
Autonomic Nervous System / physiopathology
Child, Preschool
Cystic Fibrosis / blood,  enzymology*,  physiopathology
Dopamine / blood
Dopamine beta-Hydroxylase / blood*
Middle Aged
Norepinephrine / blood
Reference Values
Reg. No./Substance:
51-41-2/Norepinephrine; EC beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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