| Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons. | |
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MedLine Citation:
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PMID: 2422168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat genomic clones were used to quantitate preprotachykinin mRNAs in the rat basal ganglia, while the tachykinin peptide products substance P and substance K were measured by radioimmunoassay. Administration of the dopamine antagonist (antipsychotic) drug haloperidol significantly decreased substance P, substance K, and both alpha (substance P encoding) and beta (substance P/substance K encoding) preprotachykinin mRNAs, suggesting a drug-induced decrease in striatonigral tachykinin biosynthesis. The time course for decreased preprotachykinin mRNAs and tachykinins apparently parallels the period of maximum risk for the development of certain antipsychotic drug-induced extrapyramidal side effects seen clinically. Tachykinin interaction with dopamine neurons may play an important role in the modulation of basal ganglia function. |
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Authors:
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M J Bannon; J M Lee; P Giraud; A Young; H U Affolter; T I Bonner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 261 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-06-19 Completed Date: 1986-06-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6640-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Striatum / drug effects, metabolism* Haloperidol / pharmacology* Kinetics Male Nerve Tissue Proteins / genetics* Neurokinin A Neurons / drug effects, metabolism* Protein Precursors / genetics* RNA, Messenger / genetics*, isolation & purification Radioimmunoassay Rats Rats, Inbred Strains Substance P / genetics* Substantia Nigra / drug effects, metabolism* Tachykinins* |
| Grant Support | |
ID/Acronym/Agency:
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MH-25642/MH/NIMH NIH HHS; MH-41388/MH/NIMH NIH HHS; RR05358/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 0/Protein Precursors; 0/RNA, Messenger; 0/Tachykinins; 0/preprotachykinin; 33507-63-0/Substance P; 52-86-8/Haloperidol; 86933-74-6/Neurokinin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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