Document Detail


Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons.
MedLine Citation:
PMID:  2422168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rat genomic clones were used to quantitate preprotachykinin mRNAs in the rat basal ganglia, while the tachykinin peptide products substance P and substance K were measured by radioimmunoassay. Administration of the dopamine antagonist (antipsychotic) drug haloperidol significantly decreased substance P, substance K, and both alpha (substance P encoding) and beta (substance P/substance K encoding) preprotachykinin mRNAs, suggesting a drug-induced decrease in striatonigral tachykinin biosynthesis. The time course for decreased preprotachykinin mRNAs and tachykinins apparently parallels the period of maximum risk for the development of certain antipsychotic drug-induced extrapyramidal side effects seen clinically. Tachykinin interaction with dopamine neurons may play an important role in the modulation of basal ganglia function.
Authors:
M J Bannon; J M Lee; P Giraud; A Young; H U Affolter; T I Bonner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  261     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-06-19     Completed Date:  1986-06-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6640-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Corpus Striatum / drug effects,  metabolism*
Haloperidol / pharmacology*
Kinetics
Male
Nerve Tissue Proteins / genetics*
Neurokinin A
Neurons / drug effects,  metabolism*
Protein Precursors / genetics*
RNA, Messenger / genetics*,  isolation & purification
Radioimmunoassay
Rats
Rats, Inbred Strains
Substance P / genetics*
Substantia Nigra / drug effects,  metabolism*
Tachykinins*
Grant Support
ID/Acronym/Agency:
MH-25642/MH/NIMH NIH HHS; MH-41388/MH/NIMH NIH HHS; RR05358/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Protein Precursors; 0/RNA, Messenger; 0/Tachykinins; 0/preprotachykinin; 33507-63-0/Substance P; 52-86-8/Haloperidol; 86933-74-6/Neurokinin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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