| Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa. | |
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MedLine Citation:
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PMID: 18977121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Excessive physical activity is commonly described as symptom of Anorexia Nervosa (AN). Activity-based anorexia (ABA) is considered an animal model for AN. The ABA model mimics severe body weight loss and increased physical activity. Suppression of hyperactivity by olanzapine in anorectic patients as well as in ABA rats suggested a role of dopamine and/or serotonin in this trait. Here, we investigated the effect of a non-selective dopamine antagonist in the ABA model. A dose-response curve of chronic treatment with the non-selective dopaminergic antagonist cis-flupenthixol was determined in the ABA model. Treatment reduced activity levels in both ad libitum fed and food-restricted rats. Treated ABA rats reduced body weight loss and increased food intake. These data support a role for dopamine in anorexia associated hyperactivity. Interestingly, in contrast to leptin treatment, food-anticipatory activity still persists in treated ABA rats. |
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Authors:
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Linda A W Verhagen; Mieneke C M Luijendijk; Jacquelien J G Hillebrand; Roger A H Adan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-01 |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 19 ISSN: 1873-7862 ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-06 Completed Date: 2009-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 153-60 Citation Subset: IM |
Affiliation:
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Rudolf Magnus Institute of Neuroscience, Department of Neuroscience & Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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pathology Analysis of Variance Animals Anorexia Nervosa / blood, drug therapy*, pathology, physiopathology* Behavior, Animal / drug effects Body Composition / drug effects Body Temperature / drug effects Body Weight / drug effects Disease Models, Animal Dopamine Antagonists / administration & dosage* Dose-Response Relationship, Drug Drug Delivery Systems / methods Eating / drug effects* Female Flupenthixol / administration & dosage* Food Deprivation / physiology Insulin / blood Leptin / blood Motor Activity / drug effects Radioimmunoassay / methods Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 0/Leptin; 11061-68-0/Insulin; 2709-56-0/Flupenthixol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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