Document Detail

Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa.
MedLine Citation:
PMID:  18977121     Owner:  NLM     Status:  MEDLINE    
Excessive physical activity is commonly described as symptom of Anorexia Nervosa (AN). Activity-based anorexia (ABA) is considered an animal model for AN. The ABA model mimics severe body weight loss and increased physical activity. Suppression of hyperactivity by olanzapine in anorectic patients as well as in ABA rats suggested a role of dopamine and/or serotonin in this trait. Here, we investigated the effect of a non-selective dopamine antagonist in the ABA model. A dose-response curve of chronic treatment with the non-selective dopaminergic antagonist cis-flupenthixol was determined in the ABA model. Treatment reduced activity levels in both ad libitum fed and food-restricted rats. Treated ABA rats reduced body weight loss and increased food intake. These data support a role for dopamine in anorexia associated hyperactivity. Interestingly, in contrast to leptin treatment, food-anticipatory activity still persists in treated ABA rats.
Linda A W Verhagen; Mieneke C M Luijendijk; Jacquelien J G Hillebrand; Roger A H Adan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-01
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  19     ISSN:  1873-7862     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-06     Completed Date:  2009-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  153-60     Citation Subset:  IM    
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience & Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Adipose Tissue / pathology
Analysis of Variance
Anorexia Nervosa / blood,  drug therapy*,  pathology,  physiopathology*
Behavior, Animal / drug effects
Body Composition / drug effects
Body Temperature / drug effects
Body Weight / drug effects
Disease Models, Animal
Dopamine Antagonists / administration & dosage*
Dose-Response Relationship, Drug
Drug Delivery Systems / methods
Eating / drug effects*
Flupenthixol / administration & dosage*
Food Deprivation / physiology
Insulin / blood
Leptin / blood
Motor Activity / drug effects
Radioimmunoassay / methods
Rats, Wistar
Reg. No./Substance:
0/Dopamine Antagonists; 0/Leptin; 11061-68-0/Insulin; 2709-56-0/Flupenthixol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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