Document Detail

Dopamine acts through Cryptochrome to promote acute arousal in Drosophila.
MedLine Citation:
PMID:  22581798     Owner:  NLM     Status:  MEDLINE    
The fruit fly, Drosophila melanogaster, is generally diurnal, but a few mutant strains, such as the circadian clock mutant Clk(Jrk), have been described as nocturnal. We report here that increased nighttime activity of Clk mutants is mediated by high levels of the circadian photoreceptor CRYPTOCHROME (CRY) in large ventral lateral neurons (l-LN(v)s). We found that CRY expression is also required for nighttime activity in mutants that have high dopamine signaling. In fact, dopamine signaling is elevated in Clk(Jrk) mutants and acts through CRY to promote the nocturnal activity of this mutant. Notably, dopamine and CRY are required for acute arousal upon sensory stimulation. Because dopamine signaling and CRY levels are typically high at night, this may explain why a chronic increase in levels of these molecules produces sustained nighttime activity. We propose that CRY has a distinct role in acute responses to sensory stimuli: (1) circadian responses to light, as previously reported, and (2) noncircadian effects on arousal, as shown here.
Shailesh Kumar; Dechun Chen; Amita Sehgal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-11
Journal Detail:
Title:  Genes & development     Volume:  26     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-08-02     Revised Date:  2014-05-14    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1224-34     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal
Biological Clocks
CLOCK Proteins / genetics,  metabolism
Circadian Rhythm
Cryptochromes / metabolism*
Dopamine / metabolism*
Drosophila Proteins / genetics,  metabolism*
Drosophila melanogaster / physiology*
Eye Proteins / metabolism*
Motor Activity
Grant Support
1R01NS048471/NS/NINDS NIH HHS; 1R56NS048471/NS/NINDS NIH HHS; R01 NS035703/NS/NINDS NIH HHS; R01 NS048471/NS/NINDS NIH HHS; R56 NS048471/NS/NINDS NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Clk protein, Drosophila; 0/Cryptochromes; 0/Drosophila Proteins; 0/Eye Proteins; 0/cryptochrome protein, Drosophila; EC Proteins; VTD58H1Z2X/Dopamine

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