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Dopamine Transporter Shown by SPECT in PLM Patients after Acute Physical Exercise.
MedLine Citation:
PMID:  22935737     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To evaluate dopamine transporter (DAT) density in periodic leg movement (PLM) patients shown by [Tc]TRODAT-1 SPECT (Single-photon Emission Computed Tomography) imaging and to determine the influence of acute physical exercise (maximal exercise test - MET) on DAT densities. METHOD: Sixteen healthy male volunteers between 45 and 65 years of age were selected to participate in the study. Each subjects (control (8) and experimental-PLM patient (8), groups) underwent baseline polysomnography (PSG) to evaluate sleep patterns and PLM index values. After obtaining PSG baselines, single photon emission computer tomography (SPECT) baselines were determined using [Tc]TRODAT-1, a selective dopamine transporter imaging ligand. Subsequently, the volunteers performed the MET in the morning, followed by a SPECT 2 hours later and PSG that night to assess the effect of acute physical exercise on DAT and sleep patterns. RESULTS: The baseline SPECT results showed marginally significantly lower DAT densities in the striatal region of the experimental group. After the MET, no significant differences were observed between groups. The results also showed a significant reduction in the PLM index in the experimental group and a significantly increased percentage of stage-1 non-REM sleep in both groups after MET. CONCLUSIONS: Our results show that PLM patients had a marginally lower DAT density in the left putamen region compared to the control group. Although the effect of acute physical exercise (MET) reduced PLM symptoms, the results suggest that this improvement was not due to DAT availability.
Authors:
Daniel Alves Cavagnolli; Andrea Maculano Esteves; Mario Luiz Vieira Castiglione; Ilza Rosa Batista; Rodrigo Afonseca Bressan; Sergio Tufik; Marco Túlio de Mello
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-29
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Psychobiology - Federal University of Sao Paulo, Brazil 2Interdisciplinary Laboratory of Clinical Neurosciences - Federal University of Sao Paulo, Brazil *The first two authors had the same contribution to this study.
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