Document Detail


Dopamine Receptor 1 Modulates the Discharge Activities of Inspiratory and Biphasic Expiratory Neurons via cAMP-Dependent Pathways.
MedLine Citation:
PMID:  23138234     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dopamine receptor 1 (D(1)R) plays an essential role in regulating respiratory activity in mammals, however, little is known about how this receptor acts to modulate the basic respiratory rhythmogenesis. Here, by simultaneously recording the discharge activities of biphasic expiratory (biphasic E) neurons/inspiratory (I) neurons and the XII nerve rootlets from brainstem slices, we found that the application of D(1)R agonist cis-(±)-1-(aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diolhydrochloride (A68930, 5 μM), or forskolin, an intracellular cAMP-increasing agent, substantially decreased respiratory cycle and expiratory time of both types of neurons, and elevated the integral amplitude and frequency of XII nerve rootlets discharge. These changes were reversed by subsequent application of their antagonists SCH-23390 and Rp-Adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt hydrate (Rp-cAMPS), respectively. Importantly, after pretreatment with Rp-cAMPS, the effects of A68930 in both types of neurons were blocked, suggestive of a cAMP-dependent action of A68930. Thus, the current study indicates that D(1)R may modulate basic breathing rhythmogenesis via cAMP-dependent mechanisms.
Authors:
Yong-Gang Jiao; Guo-Cai Li; Jun-Pao Chen; Zhong-Hai Wu; Hong-Tian Zhang
Related Documents :
3027574 - A cyclic nucleotide-gated conductance in olfactory receptor cilia.
20572674 - Beta-cyclodextrin/surface plasmon resonance detection system for sensing bitter-astring...
12826274 - Mutagenesis studies of the human mt2 melatonin receptor.
14751284 - Accumulation of ym1/2 protein in the mouse olfactory epithelium during regeneration and...
8569694 - Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a no...
9007534 - High levels of specific neuropeptide y/pancreatic polypeptide receptors in the rat hypo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Cellular and molecular neurobiology     Volume:  -     ISSN:  1573-6830     ISO Abbreviation:  Cell. Mol. Neurobiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200709     Medline TA:  Cell Mol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurology, Guangdong No. 2 Provincial People's Hospital, Guangzhou, 510317, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Osteolysis of the tibial plateau after meniscal repair with hybrid suture anchor.
Next Document:  Risk of revision for fixed versus mobile-bearing primary total knee replacements.