Document Detail


Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament.
MedLine Citation:
PMID:  21166770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Existing studies of the effect on infant temperament of the 48 base pair variable number of tandem repeats polymorphism in exon 3 of the dopamine D4 receptor gene, DRD4 VNTR, and the serotonin transporter-linked polymorphic region, 5-HTTLPR, have provided contradictory results, and age seems to be an important factor. The present study investigated the effect of these two polymorphisms on the stability of infant temperament between 4 and 9 months of age. Furthermore, the effect of a recently discovered single nucleotide polymorphism which modulates the 5-HTTLPR (rs25531) was investigated in relation to infant temperament. The study sample consisted of 90 infants, who were assessed by parental report at the two ages under consideration using the Revised Infant Behavior Questionnaire. It was found that infants carrying the 7-repeat allele of the DRD4 VNTR had higher levels of Negative Affect. Furthermore, there was an interaction between DRD4 VNTR and 5-HTTLPR genotype such that infants with the DRD4 VNTR 7-repeat allele and the highest expressing 5-HTTLPR genotype (L(A) L(A) ) had the highest level of Negative Affect. These effects were largely driven by scores on the Falling Reactivity scale. Genetic effects were stable across age. The results emphasize the need for developmental studies of genetic effects on temperament.
Authors:
K Holmboe; Z Nemoda; R M P Fearon; M Sasvari-Szekely; M H Johnson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-25
Journal Detail:
Title:  Genes, brain, and behavior     Volume:  10     ISSN:  1601-183X     ISO Abbreviation:  Genes Brain Behav.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-05     Completed Date:  2012-02-13     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101129617     Medline TA:  Genes Brain Behav     Country:  England    
Other Details:
Languages:  eng     Pagination:  513-22     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Genes, Brain and Behavior © 2011 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.
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MeSH Terms
Descriptor/Qualifier:
Affect / physiology
Alleles
Female
Genotype
Humans
Infant
Infant Behavior / physiology
Longitudinal Studies
Male
Personality Development*
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic
Receptors, Dopamine D4 / genetics*
Serotonin Plasma Membrane Transport Proteins / genetics*
Tandem Repeat Sequences
Temperament / physiology*
Grant Support
ID/Acronym/Agency:
G0701484//Medical Research Council; G0800054//Medical Research Council; G0800054//Medical Research Council; G0800054(86939)//Medical Research Council; G9715587//Medical Research Council; G9715587(62689)//Medical Research Council
Chemical
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins; 137750-34-6/Receptors, Dopamine D4
Comments/Corrections

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