Document Detail

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.
MedLine Citation:
PMID:  19853629     Owner:  NLM     Status:  MEDLINE    
In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.
Panayotis K Thanos; Rahila Habibi; Michael Michaelides; Ujval B Patel; Katherine Suchland; Brenda J Anderson; John K Robinson; Gene-Jack Wang; David K Grandy; Nora D Volkow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2009-10-22
Journal Detail:
Title:  Behavioural brain research     Volume:  207     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-13     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  508-11     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, MD, USA.
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MeSH Terms
Cocaine / administration & dosage,  pharmacology*
Conditioning, Operant / drug effects*,  physiology*
Dopamine Uptake Inhibitors / administration & dosage,  pharmacology*
Mice, Knockout
Mice, Transgenic
Receptors, Dopamine D4 / deficiency,  genetics,  metabolism*
Self Administration
Grant Support
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 137750-34-6/Receptors, Dopamine D4; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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