Document Detail


Dopamine D3 receptor ligands: recent advances in the control of subtype selectivity and intrinsic activity.
MedLine Citation:
PMID:  17274946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various pharmacological studies have implicated the dopamine D(3) receptor as an interesting therapeutic target in the treatment of different neurological disorders. Because of these putative therapeutic applications, D(3) receptor ligands with diverse intrinsic activities have been an active field of research in recent years. Separation of purely D(3)-mediated drug effects from effects produced by interactions with similar biogenic amine receptors allows to verify the therapeutic impact of D(3) receptors and to reduce possible side-effects caused by "promiscuous" receptor interactions. The requirement to gain control of receptor selectivity and in particular subtype selectivity has been a challenging task in rational drug discovery for quite a few years. In this review, recently developed structural classes of D(3) ligands are discussed, which cover a broad spectrum of intrinsic activities and show interesting selectivities.
Authors:
Frank Boeckler; Peter Gmeiner
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-12-15
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1768     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  871-87     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University Erlangen-Nürnberg, Schuhstrasse 19, 91052 Erlangen, Germany. fmb@mrc-lmb.cam.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Humans
Ligands
Molecular Sequence Data
Pharmaceutical Preparations / chemistry*
Protein Conformation
Receptors, Dopamine D3 / agonists*,  antagonists & inhibitors,  chemistry*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Ligands; 0/Pharmaceutical Preparations; 0/Receptors, Dopamine D3

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