Document Detail


Dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients.
MedLine Citation:
PMID:  11478419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies have shown a lower prevalence of tardive dyskinesia (TD) among Chinese psychiatric patients compared to Caucasian and Black patient populations. It has been hypothesized that pharmacogenetic factors may underlie this cross-cultural difference. Due to the important implications of the dopamine D3 receptor gene (DRD3) in motor control, we investigated the frequency of polymorphic serine (ser) to glycine (gly) substitution of the gene DRD3 in Chinese schizophrenic patients. The sample size consisted of 65 patients with TD and 66 without TD. Patients were assessed for the severity of TD, the presence of akathisia and parkinsonian symptoms and were subsequently genotyped. We found no evidence that the dopamine D3 receptor gene is likely to confer susceptibility to the development of tardive dyskinesia in Chinese patients with schizophrenia.
Authors:
M M Garcia-Barceló; L C Lam; G S Ungvari; V K Lam; W K Tang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  108     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2001  
Date Detail:
Created Date:  2001-07-31     Completed Date:  2001-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antipsychotic Agents / adverse effects
Asian Continental Ancestry Group / genetics
Dyskinesia, Drug-Induced / genetics*
Female
Genotype
Hong Kong
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Dopamine D2 / genetics*
Receptors, Dopamine D3
Schizophrenia / drug therapy,  genetics*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/DRD3 protein, human; 0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3

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