Document Detail

Dopamine D1 receptors control exercise hyperpnoea in mice.
MedLine Citation:
PMID:  23024370     Owner:  NLM     Status:  Publisher    
Previously, we undertook simultaneous recording of ventilation and pulmonary gas exchange in mice. These studies revealed that dopamine D2 receptors participate in exercise hyperpnoea via behavioural control of ventilation with unchanged pulmonary gas exchange. Here we examined the hypothesis that D1 receptors also contribute to exercise hyperpnoea using the simultaneous recording technique and a D1 receptor antagonist (SCH 23390 (SCH)) which crosses the blood-brain barrier. The respiratory responses of mice injected with saline and SCH (50 μg/kg body weight; i.p.) were compared during constant-load exercise at 6 m/min. Each mouse was set in an airtight treadmill chamber equipped with a differential pressure transducer and open-circuit system with a mass spectrometer. At rest, SCH mice had significantly reduced respiratory frequency (fR), minute ventilation (V) and pulmonary gas exchange compared with saline mice. Ventilation during hyperoxic-gas inhalation and hypercapnic ventilatory responses between groups were similar. Abrupt increases and sequential declines to the steady-state level were produced by treadmill exercise in both mice groups. SCH lowered the increased levels of fR, tidal volume and V during the steady state, but did not significantly affect the initial increase in breathing. SCH also reduced O2 uptake (VO2) and body temperature throughout treadmill exercise. These data suggest that D1 receptors contribute to a resting-ventilation level and exercise hyperpnoea during the steady state in parallel with metabolic changes. D1 receptors in hypothalamic nuclei could be involved in this modulation. Differences between the effects of D1 and D2 receptors were demonstrated in exercise hyperpnoea.
Michiko Iwase; Masahiko Izumizaki; Naoto Tsuchiya; Ikuo Homma
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Showa University School of Medicine.
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