| Dopamine D1 receptor changes due to caesarean section birth: effects of anesthesia, developmental time course, and functional consequences. | |
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MedLine Citation:
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PMID: 12061868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is an epidemiological association between increased obstetric complications and disorders involving CNS dopamine dysregulation, such as schizophrenia. In light of this, a rat model of global hypoxia during Caesarean section (C-section) birth has been used to directly test if birth complications can produce long-term dopaminergic dysregulation. Previous studies have shown that, compared to vaginal birth, C-section birth alone (without additional global hypoxia) is sufficient to increase D1-like receptor binding in rat brain at adulthood. The current study examined (1) the developmental time course of changes in D1-like or D2-like receptors following C-section birth; (2) whether C-section birth from isoflurane-anesthetized dams also results in altered D1-like receptor levels, as does C-section from decapitated dams; and (3) behavioral responses to D1 and D2 agonists in rats born vaginally compared to C-section. Increases in nucleus accumbens D1-like receptor binding due to C-section birth were observed only at adulthood (3 months) but not prepubertally (1 month or 2 weeks). D2-like receptor binding levels were unaffected by C-section birth across the three developmental time points. Compared to vaginal birth, D1-like receptors were increased following C-section birth from isoflurane-anesthetized dams, as well as from decapitated dams. Adult rats that had been born by C-section showed enhanced D1 potentiation of D2-induced locomotor behavior. These studies indicate that C-section birth, from either anesthetized or unanesthetized dams, results in postpubertal increases in D1-like receptor binding and enhanced functional responses to D1 receptor activation. |
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Authors:
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Patricia Boksa; Ying Zhang; Alain Bestawros |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental neurology Volume: 175 ISSN: 0014-4886 ISO Abbreviation: Exp. Neurol. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-13 Completed Date: 2002-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 388-97 Citation Subset: IM |
Copyright Information:
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(c) 2002 Elsevier Science (USA). |
Affiliation:
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Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada. patricia.boksa@mcgill.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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pharmacology Amphetamines / pharmacology Anesthetics, Inhalation / pharmacology* Animals Brain / drug effects, embryology, metabolism* Cesarean Section* Dopamine Agonists / pharmacology Female Isoflurane / pharmacology* Labor, Obstetric / metabolism* Motor Activity / drug effects Pregnancy Rats Rats, Sprague-Dawley Receptors, Dopamine D1 / metabolism* Receptors, Dopamine D2 / metabolism Schizophrenia / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 0/Anesthetics, Inhalation; 0/Dopamine Agonists; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 26675-46-7/Isoflurane; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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