Document Detail

Dopamine D1 receptor changes due to caesarean section birth: effects of anesthesia, developmental time course, and functional consequences.
MedLine Citation:
PMID:  12061868     Owner:  NLM     Status:  MEDLINE    
There is an epidemiological association between increased obstetric complications and disorders involving CNS dopamine dysregulation, such as schizophrenia. In light of this, a rat model of global hypoxia during Caesarean section (C-section) birth has been used to directly test if birth complications can produce long-term dopaminergic dysregulation. Previous studies have shown that, compared to vaginal birth, C-section birth alone (without additional global hypoxia) is sufficient to increase D1-like receptor binding in rat brain at adulthood. The current study examined (1) the developmental time course of changes in D1-like or D2-like receptors following C-section birth; (2) whether C-section birth from isoflurane-anesthetized dams also results in altered D1-like receptor levels, as does C-section from decapitated dams; and (3) behavioral responses to D1 and D2 agonists in rats born vaginally compared to C-section. Increases in nucleus accumbens D1-like receptor binding due to C-section birth were observed only at adulthood (3 months) but not prepubertally (1 month or 2 weeks). D2-like receptor binding levels were unaffected by C-section birth across the three developmental time points. Compared to vaginal birth, D1-like receptors were increased following C-section birth from isoflurane-anesthetized dams, as well as from decapitated dams. Adult rats that had been born by C-section showed enhanced D1 potentiation of D2-induced locomotor behavior. These studies indicate that C-section birth, from either anesthetized or unanesthetized dams, results in postpubertal increases in D1-like receptor binding and enhanced functional responses to D1 receptor activation.
Patricia Boksa; Ying Zhang; Alain Bestawros
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental neurology     Volume:  175     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-13     Completed Date:  2002-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  388-97     Citation Subset:  IM    
Copyright Information:
(c) 2002 Elsevier Science (USA).
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada.
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MeSH Terms
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
Amphetamines / pharmacology
Anesthetics, Inhalation / pharmacology*
Brain / drug effects,  embryology,  metabolism*
Cesarean Section*
Dopamine Agonists / pharmacology
Isoflurane / pharmacology*
Labor, Obstetric / metabolism*
Motor Activity / drug effects
Rats, Sprague-Dawley
Receptors, Dopamine D1 / metabolism*
Receptors, Dopamine D2 / metabolism
Schizophrenia / metabolism
Reg. No./Substance:
0/Amphetamines; 0/Anesthetics, Inhalation; 0/Dopamine Agonists; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 26675-46-7/Isoflurane; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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