| Donor species complement after liver xenotransplantation. The mechanism of protection from hyperacute rejection. | |
MedLine Citation:
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PMID: 8154040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in prolonged survival of hamster hearts to 25 days without deterioration effect in the liver xenografts. This effect was species-specific because third-party mouse heart grafts in OLT rats were hyperacutely rejected in minutes if either active or heat inactivated antimouse HS was given. In cytotoxicity experiments, the complement in OLT serum produced weak lysis of hamster lymphocytes, while efficiently doing so with mouse cell targets. Because normal hamster serum caused no lysis at all of hamster target cells, the residual low-grade lysis of OLT serum was possibly being mediated by extrahepatic sources of rat C. In conclusion, the homology of C and target cells represents a mechanism of protection that the liver confers to other organs, and that is mostly easily seen in xenografts but may be allospecifically operational with allografts as well within the limits of MHC restriction. |
Authors:
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L A Valdivia; J J Fung; A J Demetris; S Celli; F Pan; M Tsugita; T E Starzl |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Transplantation Volume: 57 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-05-06 Completed Date: 1994-05-06 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 918-22 Citation Subset: IM |
Affiliation:
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Pittsburgh Transplant Institute, University of Pittsburgh Health Science Center, Pennsylvania. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Complement Activation Complement Inactivator Proteins / pharmacology Complement System Proteins / physiology* Cricetinae Graft Rejection / prevention & control Heart Transplantation / immunology Immune Sera / administration & dosage Liver Transplantation / immunology* Male Mesocricetus Rats Rats, Inbred Lew Species Specificity Transplantation, Heterologous* / immunology |
| Grant Support | |
ID/Acronym/Agency:
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DK 29961/DK/NIDDK NIH HHS; R01 DK029961-19/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Complement Inactivator Proteins; 0/Immune Sera; 9007-36-7/Complement System Proteins |
| Comments/Corrections | |
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