Document Detail

Donor species complement after liver xenotransplantation. The mechanism of protection from hyperacute rejection.
MedLine Citation:
PMID:  8154040     Owner:  NLM     Status:  MEDLINE    
Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in prolonged survival of hamster hearts to 25 days without deterioration effect in the liver xenografts. This effect was species-specific because third-party mouse heart grafts in OLT rats were hyperacutely rejected in minutes if either active or heat inactivated antimouse HS was given. In cytotoxicity experiments, the complement in OLT serum produced weak lysis of hamster lymphocytes, while efficiently doing so with mouse cell targets. Because normal hamster serum caused no lysis at all of hamster target cells, the residual low-grade lysis of OLT serum was possibly being mediated by extrahepatic sources of rat C. In conclusion, the homology of C and target cells represents a mechanism of protection that the liver confers to other organs, and that is mostly easily seen in xenografts but may be allospecifically operational with allografts as well within the limits of MHC restriction.
L A Valdivia; J J Fung; A J Demetris; S Celli; F Pan; M Tsugita; T E Starzl
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Transplantation     Volume:  57     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-05-06     Completed Date:  1994-05-06     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  918-22     Citation Subset:  IM    
Pittsburgh Transplant Institute, University of Pittsburgh Health Science Center, Pennsylvania.
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MeSH Terms
Complement Activation
Complement Inactivator Proteins / pharmacology
Complement System Proteins / physiology*
Graft Rejection / prevention & control
Heart Transplantation / immunology
Immune Sera / administration & dosage
Liver Transplantation / immunology*
Rats, Inbred Lew
Species Specificity
Transplantation, Heterologous* / immunology
Grant Support
Reg. No./Substance:
0/Complement Inactivator Proteins; 0/Immune Sera; 9007-36-7/Complement System Proteins

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