Document Detail

Donor cell leukemia: report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature.
MedLine Citation:
PMID:  10602169     Owner:  NLM     Status:  MEDLINE    
We report the case of a man with chronic myelocytic leukemia (CML) and a 46,XY,t(5;9;22) karyotype who developed acute myelocytic leukemia (AML) with a 45,X,t(8;21) karyotype 11 years after bone marrow transplantation (BMT) from his HLA-matched sister. Fluorescent in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the new leukemia to be of donor cell origin. Donor cell leukemia (DCL) after BMT is rare. Our review of the literature found 15 cases following BMT for leukemia and 2 cases after BMT for benign hematological disorders. In fewer than half the reported cases were molecular studies available to confirm the cytogenetic evidence for DCL, and the longest previously reported interval between BMT and DCL was 6 years.
L D Cooley; D A Sears; M M Udden; W R Harrison; K R Baker
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  63     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-21     Completed Date:  2000-01-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-53     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Department of Pathology and Laboratory Medicine, The University of Texas Medical School, Houston, Texas, USA.
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MeSH Terms
Bone Marrow Transplantation / adverse effects*
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / etiology*,  genetics
Tandem Repeat Sequences
Time Factors
Tissue Donors*
Translocation, Genetic

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