Document Detail


Donor HL-A incompatibility and lymphocytotoxic antibody response in human renal allotransplantation.
MedLine Citation:
PMID:  50657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When 81 recipients of primary renal allografts were examined for the influence of donor HL-A incompatibilities (DIC) on the survival of allografts, an association was found between greater DIC and not only an increased loss of allografts in the 1st year, but also a decreased survival of transplants in the subsequent years. However, three allografts with no DIC were rejected, whereas nine others with three to four imcompatibilities have functioned well for 1-5 years. A surprisingly high proportion (52%) of 81 renal allograft recipients produced lymphocytotoxic antibodies which lack HL-A specificity but apparently detect a polymorphic antigenic system on normal human lymphocytes. Only three patients who rejected the allografts made detectable circulating antibodies specific to DIC. However, when patients received grafts with fewer DIC, there was a greater number of no antibody or low frequency antibody producers, whereas with a greater number of DIC there was an increased occurrence of high frequency antibody producers. These results suggest that HL-A as well as non-HL-A systems may play a significant role in the success of allotransplantation. Although the presence of non-HL-A antibodies was not always associated with allograft loss, further characterization of these antibodies may reveal a new genetic system(s).
Authors:
K K Mittal; B D Kakan; J J Bergan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  19     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-11-05     Completed Date:  1975-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibody Specificity
Antigen-Antibody Reactions
Antilymphocyte Serum / analysis*
Cytotoxicity Tests, Immunologic
Epitopes
Graft Rejection / etiology
Histocompatibility Antigens*
Histocompatibility Testing*
Humans
Kidney Transplantation*
Tissue Donors
Transplantation, Homologous*
Chemical
Reg. No./Substance:
0/Antilymphocyte Serum; 0/Epitopes; 0/Histocompatibility Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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