| Donepezil treatment in Alzheimer's disease patients with and without cerebrovascular lesions: a preliminary report. | |
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MedLine Citation:
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PMID: 20825496 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: Donepezil has not been evaluated in Korean patients with Alzheimer's disease (AD) for up to 1 year. The objectives of this study were to evaluate the differential efficacy of donepezil in Korean AD patients with and without concomitant cerebrovascular lesions (CVL). METHODS: This study was a 48-week open-label trial of donepezil in patients with probable AD of mild to moderate severity. CVL were evaluated through magnetic resonance imaging (MRI) findings within 3 months. Efficacy analyses were performed for cognitive, behavioral and functional outcome measures. RESULTS: Concomitant CVL were documented in 35 (30.7%) of the patients on MRI. Seventy-nine (69.3%) of the patients were considered not to have concomitant CVL. The mean Mini-Mental State Examination scores of both patients with and without CVL showed improvement at each evaluation. However, there was no statistical difference in improvement between the groups. CONCLUSION: The presence of CVL should not deter clinicians from treating AD with donepezil. |
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Authors:
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Hae-Ri Na; SangYun Kim; Seong-Hye Choi; Dong-Won Yang; Hee-Joon Bae; Jung-Eun Kim; Mee-Young Park; Yong-Soo Shim; Byung-Kun Kim; Jae-Cheol Kwon; Bong-Goo Yoo; Byeong-Chae Kim; Jung-Seok Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-03 |
Journal Detail:
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Title: Geriatrics & gerontology international Volume: 11 ISSN: 1447-0594 ISO Abbreviation: Geriatr Gerontol Int Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135738 Medline TA: Geriatr Gerontol Int Country: Japan |
Other Details:
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Languages: eng Pagination: 90-7 Citation Subset: IM |
Copyright Information:
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© 2010 Japan Geriatrics Society. |
Affiliation:
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Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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