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Donepezil treatment in Alzheimer's disease patients with and without cerebrovascular lesions: a preliminary report.
MedLine Citation:
PMID:  20825496     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: Donepezil has not been evaluated in Korean patients with Alzheimer's disease (AD) for up to 1 year. The objectives of this study were to evaluate the differential efficacy of donepezil in Korean AD patients with and without concomitant cerebrovascular lesions (CVL).
METHODS: This study was a 48-week open-label trial of donepezil in patients with probable AD of mild to moderate severity. CVL were evaluated through magnetic resonance imaging (MRI) findings within 3 months. Efficacy analyses were performed for cognitive, behavioral and functional outcome measures.
RESULTS: Concomitant CVL were documented in 35 (30.7%) of the patients on MRI. Seventy-nine (69.3%) of the patients were considered not to have concomitant CVL. The mean Mini-Mental State Examination scores of both patients with and without CVL showed improvement at each evaluation. However, there was no statistical difference in improvement between the groups.
CONCLUSION: The presence of CVL should not deter clinicians from treating AD with donepezil.
Authors:
Hae-Ri Na; SangYun Kim; Seong-Hye Choi; Dong-Won Yang; Hee-Joon Bae; Jung-Eun Kim; Mee-Young Park; Yong-Soo Shim; Byung-Kun Kim; Jae-Cheol Kwon; Bong-Goo Yoo; Byeong-Chae Kim; Jung-Seok Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-03
Journal Detail:
Title:  Geriatrics & gerontology international     Volume:  11     ISSN:  1447-0594     ISO Abbreviation:  Geriatr Gerontol Int     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135738     Medline TA:  Geriatr Gerontol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  90-7     Citation Subset:  IM    
Copyright Information:
© 2010 Japan Geriatrics Society.
Affiliation:
Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea.
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