| Donepezil in Alzheimer's disease: what to expect after 3 years of treatment in a routine clinical setting. | |
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MedLine Citation:
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PMID: 17312368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Clinical short-term trails have shown positive effects of donepezil treatment in patients with Alzheimer's disease. The outcome of continuous long-term treatment in the routine clinical settings remains to be investigated. METHODS: The Swedish Alzheimer Treatment Study (SATS) is a descriptive, prospective, longitudinal, multicentre study. Four hundred and thirty-five outpatients with the clinical diagnosis of Alzheimer's disease, received treatment with donepezil. Patients were assessed with Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog), global rating (CIBIC) and Instrumental Activities of Daily Living (IADL) at baseline and every 6 months for a total period of 3 years. RESULTS: The mean MMSE change from baseline was positive for more than 6 months and in subgroups of patients for 12 months. After 3 years of treatment the mean change from baseline in MMSE-score was 3.8 points (95% CI, 3.0-4.7) and the ADAS-cog rise was 8.2 points (95% CI, 6.4-10.1). This is better than expected in untreated historical cohorts, and better than the ADAS-cog rise calculated by the Stern equation (15.6 points; 95% CI, 14.5-16.6). After 3 years with 38% of the patients remaining, 30% of the them were unchanged or improved in the global assessment. CONCLUSION: Three-year donepezil treatment showed a positive global and cognitive outcome in the routine clinical setting. |
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Authors:
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Asa K Wallin; Niels Andreasen; Sture Eriksson; Stellan Båtsman; Birgitta Nasman; Anne Ekdahl; Lena Kilander; Mikaela Grut; Marie Rydén; Anders Wallin; Mikael Jonsson; Hasse Olofsson; Elisabeth Londos; Carina Wattmo; Maria Eriksdotter Jonhagen; Lennart Minthon; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2006-12-18 |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 23 ISSN: 1420-8008 ISO Abbreviation: Dement Geriatr Cogn Disord Publication Date: 2007 |
Date Detail:
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Created Date: 2007-02-22 Completed Date: 2007-04-26 Revised Date: 2008-03-24 |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: Switzerland |
Other Details:
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Languages: eng Pagination: 150-60 Citation Subset: IM |
Affiliation:
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Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden. asa.k.wallin@skane.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / drug therapy* Cognition / drug effects* Disease Progression Female Humans Indans / therapeutic use* Longitudinal Studies Male Middle Aged Neuropsychological Tests Nootropic Agents / therapeutic use* Piperidines / therapeutic use* Prospective Studies Psychiatric Status Rating Scales Statistics, Nonparametric Sweden Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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