Document Detail


Domperidone: ventricular arrhythmia and sudden death (continued).
MedLine Citation:
PMID:  22852288     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Domperidone, a "hidden" neuroleptic, is used for symptomatic treatment of gastroesophageal reflux disease, despite its uncertain efficacy. The intravenous form was withdrawn from the market in the 1980s following deaths due to cardiac arrhythmias. QT prolongation leading to cardiac arrhythmias, including life-threatening torsades de pointes, has also been attributed to oral domperidone. In 2010, two case-control studies, one Canadian and one Dutch, showed that patients who died suddenly or had severe ventricular arrhythmias were statistically significantly more likely than controls to have been exposed to domperidone. In practice, given its uncertain efficacy and a disproportionate risk of sudden death and severe ventricular arrhythmia, domperidone should not be used.
Authors:
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  21     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  183     Citation Subset:  T    
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