Document Detail


Domperidone and long QT syndrome.
MedLine Citation:
PMID:  20394569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Domperidone is a prokinetic agent widely prescribed in adults and children with gastrointestinal disorders. Recently several Regulatory Agencies published safety information on the risk of long QT syndrome associated with the use of domperidone. We conducted a literature review using PubMed (1966 - Jan 2010) with the aim to locate articles on ventricular arrhytmias, Sudden Cardiac Death (SCD), long QT syndrome and Torsade de Pointes (TdP) following domperidone administration. Twenty-two papers were included in the review: three studies in vitro models, one animal study, five case reports/series, twelve clinical studies and one editorial. In vitro studies demonstrated cardiac electrophysiological effects of domperidone on the rapid component of the cardiac delayed rectifier K(+) current (I(Kr)) through the blockade of channels encoded by the Human Ether-a-go-go Related Gene (HERG). A total of fourteen cases of cardiotoxicity following intravenous (12 cases) or oral (2 cases) domperidone administration from case reports/series were identified. A case - control study, performed on a general practice observational database reported an OR: 3.8 (95% CI: 1.5-9.7) for SCD after domperidone exposure. Prescribers and other healthcare professionals should take into account the risk of QT syndrome in domperidone users and avoid administering domperidone in patients concomitantly taking strong CYP3A4 inhibitors or other QT prolonging drugs.
Authors:
Marco Rossi; Giorgio Giorgi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current drug safety     Volume:  5     ISSN:  2212-3911     ISO Abbreviation:  Curr Drug Saf     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-13     Completed Date:  2010-10-22     Revised Date:  2012-07-19    
Medline Journal Info:
Nlm Unique ID:  101270895     Medline TA:  Curr Drug Saf     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Affiliation:
Department of Pharmacology Giorgio Segre, University of Siena, Strada delle Scotte,6, 53100 Siena, Italy. marcorss@alice.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Arrhythmias, Cardiac / chemically induced
Child
Death, Sudden, Cardiac / etiology
Domperidone / adverse effects*
Dopamine Antagonists / adverse effects*
Drug Interactions
Humans
Long QT Syndrome / chemically induced*
Torsades de Pointes / chemically induced
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 57808-66-9/Domperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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