| Domperidone, a DA2-specific dopamine antagonist, has no effect on the renal or haemodynamic response to atrial natriuretic peptide in man. | |
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MedLine Citation:
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PMID: 2974769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Animal experiments have suggested that the renal effects of atrial natriuretic peptide (ANP) are dependent on dopaminergic activation, predominantly of the DA1-receptor. In man, there is evidence of dependence on the DA2-receptor for the natriuresis produced by central blood volume expansion. 2. Six normal volunteers underwent infusions of alpha-human ANP preceded by domperidone (a DA2-antagonist) or placebo. Eight volunteers underwent a 3 h period of 10 degrees head-down tilt also preceded by domperidone or placebo. 3. Both the ANP infusion and head-down tilt produced a significant diuresis and natriuresis, neither of which was antagonized by the presence of domperidone. 4. The ANP infusion significantly reduced diastolic blood pressure and produced significant increases in the Doppler-measured aortic blood velocity variables of peak velocity and maximal acceleration. Domperidone had an independent effect of increasing blood pressure but did not appear to have a specific interaction with the haemodynamic effects of ANP. 5. Head-down tilt reduced mean arterial pressure and heart rate and increased maximal acceleration. Again, an independent effect of domperidone was seen on blood pressure. Heart rate and maximal acceleration showed similar changes in the presence of domperidone. 6. Domperidone does not antagonize the renal or haemodynamic effects of ANP and if dopaminergic activation is necessary for the renal action of ANP it is unlikely to be mediated by the DA2-receptor. |
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Authors:
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M J Allen; V T Ang; E D Bennett |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 75 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-02-21 Completed Date: 1989-02-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 569-75 Citation Subset: IM; S |
Affiliation:
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Department of Medicine One, St George's Hospital Medical School, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Natriuretic Factor
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pharmacology* Blood Pressure / drug effects Diuresis / drug effects Domperidone / pharmacology* Hemodynamics / drug effects* Humans Kidney / drug effects* Posture Receptors, Dopamine / drug effects* Receptors, Dopamine D2 |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 0/Receptors, Dopamine D2; 57808-66-9/Domperidone; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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