Document Detail

Domoic acid in Portuguese shellfish and fish.
MedLine Citation:
PMID:  11137551     Owner:  NLM     Status:  MEDLINE    
The presence of domoic acid (DA) in Portuguese shellfish is a recurrent event that affects shellfish resources several times a year, mainly in spring and autumn. Levels of domoic acid as high as twice the regulatory level of 20 microg DA/g tissue are not unusual. When several shellfish species are exploited in the same restricted area, common cockle (Cerastoderma edule) and carpet shell (Venerupis pullastra) are usually amongst the most toxic, followed by peppery furrow shell, clam, mussel, oyster and razor clam. In whole sardine, domoic acid was detected in levels exceeding sometimes the regulatory limit. Fortunately, toxicity is restricted to the gut content, and does not accumulate in muscle tissue. In brain tissue, domoic acid was detected in levels generally below 1 microg/g. Domoic acid was confirmed by spectra acquired with a diode-array detector. The most toxic samples were confirmed by mass spectrometry.
P Vale; M A Sampayo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  39     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  893-904     Citation Subset:  IM    
Instituto de Investigação das Pescas e do Mar, Av. BrasIlia, 1400-049 Lisbon, Portugal.
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MeSH Terms
Chromatography, High Pressure Liquid
Fish Products / analysis*
Kainic Acid / analogs & derivatives*,  analysis*,  toxicity
Mass Spectrometry
Shellfish / analysis*
Reg. No./Substance:
14277-97-5/domoic acid; 487-79-6/Kainic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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