Document Detail

Dominant effect of supplemented-sucrose on the low protein diet-induced increase in blood pressure of Sprague-Dawley rats.
MedLine Citation:
PMID:  11710758     Owner:  NLM     Status:  MEDLINE    
A low-protein diet (LPD) is known to affect the regulation of hemodynamics, and could contribute to the genesis of hypertension. We investigated the mechanism for the LPD-induced elevation of blood pressure in 52 Sprague-Dawley rats. Rats fed the LPD for 8 weeks showed a significantly higher blood pressure than those fed on a normal-protein diet (NPD) when the LPD included sucrose as a predominant component of carbohydrate (LPD with a high sucrose content, 135 +/- 2 mmHg; NPD, 124 +/- 2 mmHg; p<0.05). However, LPD with a low sucrose content, in which corn starch was the main component of carbohydrate, did not have a hypertensive effect (125 +/- 2 mmHg). Urinary epinephrine and norepinephrine excretion was significantly higher in the LPD high-sucrose group than in the NPD and LPD low-sucrose groups, and there was a significant positive correlation between urinary norepinephrine excretion and systolic blood pressure. Urinary nitric oxide excretion was no different between these groups, and 2 % L-arginine administration exerted no antihypertensive effect on the LPD-induced elevation of blood pressure. Sodium restriction also did not attenuate the LPD-induced elevation of blood pressure. These results suggest that the effect of LPD on blood pressure could be interpreted as the effect of the high sucrose content supplemented to the LPD rather than the direct effect of protein restriction, and that the stimulation of sympathetic nervous activity was associated with this elevation of blood pressure.
M Endoh; A Kunieda; T Yoneyama; K Ohishi; A Hishida; H Kumagai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  23     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-16     Completed Date:  2002-03-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  569-78     Citation Subset:  IM    
Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
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MeSH Terms
Blood Pressure*
Diet, Protein-Restricted / adverse effects*
Dietary Carbohydrates / administration & dosage,  adverse effects*
Epinephrine / urine
Hypertension / etiology*,  urine
Norepinephrine / urine
Rats, Sprague-Dawley
Sucrose / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Dietary Carbohydrates; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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