| Dominant anti-vagal effect of pentobarbital on cardiac responses to intracardiac autonomic nerve stimulation in the dog. | |
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MedLine Citation:
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PMID: 11459129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The isolated canine atrium was perfused by heparinized blood of the donor dog. An adequate dose of pentobarbital that induced a potent hypotension in the donor did not produce any significant change in the atrial rate and developed tension in the isolated atrium perfused with donor's blood. Pentobarbital in doses that modified neither cardiac responses to intracardiac adrenergic nerve stimulation nor exogenously given norepinephrine or acetylcholine significantly inhibited intracardiac vagal responses. From these results, it is concluded that a large dose of pentobarbital has a dominant antivagal effect in the heart. |
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Authors:
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S Chiba; M Tsuboi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 86 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-07-18 Completed Date: 2001-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: Japan |
Other Details:
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Languages: eng Pagination: 248-50 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan. Chiba@sch.md.shinshu-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Pathways / drug effects*, physiology* Blood Pressure / drug effects, physiology Dogs Electric Stimulation Heart Atria / drug effects, innervation Heart Conduction System / physiology* Heart Rate / drug effects, physiology Hypnotics and Sedatives / administration & dosage, pharmacology* Injections, Intra-Arterial Injections, Intravenous Organ Culture Techniques Pentobarbital / administration & dosage, pharmacology* Vagus Nerve / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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