| Dominant T-cell epitopes of filarial BmALT-2 and their cytokine profile in BALB⁄c mice. | |
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MedLine Citation:
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PMID: 21086716 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Filarial nematodes down-regulate the host immune response to establish infection by inducing IL-10-mediated T-cell suppression.Abundant larval transcript (ALT) proteins are of major interest as they are expressed abundantly in the L3 stage, implicated in protective immunity and may play a role in immune evasion. The T-cell epitopes of BmALT-2 and the cytokine responses induced by these peptides were investigated in a mouse model using synthetic peptides, which could be exploited in the design of a potent epitope-based vaccine. Five regions were found to carry T-cell epitopes inducing high levels of cellular proliferation. The regions 55–68 and 73–91 of ALT-2 induced very high levels of IL-10 secretion and hence could be involved in immunomodulation in the host. |
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Authors:
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J Madhumathi; P R Prince; D Nageswara Rao; P Kaliraj |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Parasite immunology Volume: 32 ISSN: 1365-3024 ISO Abbreviation: Parasite Immunol. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910948 Medline TA: Parasite Immunol Country: England |
Other Details:
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Languages: eng Pagination: 760-3 Citation Subset: IM |
Affiliation:
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Centre For Biotechnology, Anna University, Chennai, Tamil Nadu, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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