| Dominance of E. coli phagocytosis over LPS in the inflammatory response of microglia. | |
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MedLine Citation:
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PMID: 20655116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CNS bacterial infections are prevalent in neonates, the immune-compromised and elderly. During peripheral infections, macrophages employ multiple pattern recognition receptors (PRRs) to respond to pathogens, but less is known about brain microglia. We assessed microglial expression of PRRs, compared responses to whole E. coli and LPS, and tested the hypothesis that bacteria modulate the response to LPS. LPS increased the microglial phagocytic capacity, and changed expression of CD14, CR3, Fcgr1, Fcgr3a, TLR4, MARCO, MHCII, NOD2, TLR9 and SR-A, differently from stimulation with whole E. coli. Importantly, when added with LPS, E. coli dominated the microglial responses for 11/13 genes examined. |
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Authors:
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Vishanthan Sivagnanam; Xiaoping Zhu; Lyanne C Schlichter |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-22 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 227 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 111-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Toronto Western Research Institute, MC9-417; 399 Bathurst Street, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Cells, Cultured Escherichia coli Infections / immunology*, microbiology, pathology* Gene Expression Regulation / immunology* Immunodominant Epitopes / physiology Inflammation Mediators / physiology* Lipopolysaccharides / physiology* Microglia / immunology*, microbiology, pathology* Phagocytosis / immunology* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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MT-13657//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Immunodominant Epitopes; 0/Inflammation Mediators; 0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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