Document Detail


Dominance of E. coli phagocytosis over LPS in the inflammatory response of microglia.
MedLine Citation:
PMID:  20655116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CNS bacterial infections are prevalent in neonates, the immune-compromised and elderly. During peripheral infections, macrophages employ multiple pattern recognition receptors (PRRs) to respond to pathogens, but less is known about brain microglia. We assessed microglial expression of PRRs, compared responses to whole E. coli and LPS, and tested the hypothesis that bacteria modulate the response to LPS. LPS increased the microglial phagocytic capacity, and changed expression of CD14, CR3, Fcgr1, Fcgr3a, TLR4, MARCO, MHCII, NOD2, TLR9 and SR-A, differently from stimulation with whole E. coli. Importantly, when added with LPS, E. coli dominated the microglial responses for 11/13 genes examined.
Authors:
Vishanthan Sivagnanam; Xiaoping Zhu; Lyanne C Schlichter
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-22
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  227     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  111-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Toronto Western Research Institute, MC9-417; 399 Bathurst Street, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Cells, Cultured
Escherichia coli Infections / immunology*,  microbiology,  pathology*
Gene Expression Regulation / immunology*
Immunodominant Epitopes / physiology
Inflammation Mediators / physiology*
Lipopolysaccharides / physiology*
Microglia / immunology*,  microbiology,  pathology*
Phagocytosis / immunology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
MT-13657//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Immunodominant Epitopes; 0/Inflammation Mediators; 0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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