| Domiciliary oxygen therapy improves sub-maximal exercise capacity and quality of life in chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 18403260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: A high prevalence of nocturnal hypoxia is noted in patients with chronic heart failure (CHF). Nocturnal hypoxia can be reversed by nasal oxygen or non-invasive assisted ventilation. However, controversy exists over the use of oxygen in CHF. We studied the effects of nocturnal nasal oxygen in CHF to demonstrate its effects on 6-min walk test, quality of life (QOL), NTproBNP, and echocardiographic parameters. METHODOLOGY: Ten patients aged 70+/-9 years received domiciliary oxygen (4 l/min) for one month. Oxygen was administered for a minimum of 8h every night via nasal prongs. RESULTS: A 17% improvement was seen in the 6-min walk test, 298+/-98 m to 351+/-100 m (p=0.005) and a 27% improvement in the QOL, which improved from 26+/-12 to 19+/-7 (p=0.017). Acquired echocardiographic measures including ejection fraction, pulmonary pressure and diastolic parameters did not change. CONCLUSION: Nocturnal nasal oxygen has a significant impact on sub-maximal exercise capacity and QOL in CHF. Although a previous study has demonstrated harmful haemodynamic effects of acute oxygen administration in CHF; we did not detect any change in echocardiographic parameters using current two-dimensional imaging and Doppler studies. The lack of improvement in cardiac parameters suggests a peripheral mode of action. |
| | |
Authors:
|
Biju Paul; Majo Joseph; Carmine G De Pasquale |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-09 |
Journal Detail:
|
Title: Heart, lung & circulation Volume: 17 ISSN: 1444-2892 ISO Abbreviation: Heart Lung Circ Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-05-13 Completed Date: 2008-07-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100963739 Medline TA: Heart Lung Circ Country: Australia |
Other Details:
|
Languages: eng Pagination: 220-3 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Flinders Medical Centre, Adelaide 5042, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anoxia / therapy Exercise Test Exercise Tolerance* Female Heart Failure / physiopathology, therapy* Humans Male Middle Aged Oxygen Inhalation Therapy / methods* Quality of Life Self Administration Stroke Volume / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence and risk factors for chemical sensitivity and sensory hyperreactivity in teenagers.
Next Document: Evaluation of the extracardiac conduit modification of the Fontan operation for thrombus formation u...