Document Detail

Domiciliary oxygen for chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  16235285     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Domiciliary oxygen therapy has become one of the major forms of treatment for hypoxaemic chronic obstructive pulmonary disease (COPD) patients.
OBJECTIVES: To determine the effect of domiciliary oxygen therapy on survival and quality of life in patients with COPD.
SEARCH STRATEGY: Randomised controlled trials (RCTs) were identified using the Cochrane Airways Group COPD register using the search terms: home OR domiciliary AND oxygen. Searches were current as of January 2005.
SELECTION CRITERIA: Any RCT in patients with hypoxaemia and COPD that compared long term domiciliary or home oxygen therapy with a control treatment.
DATA COLLECTION AND ANALYSIS: Data extraction was performed independently by two reviewers.
MAIN RESULTS: Six randomised controlled trials were identified. Survival data was aggregated from two trials of the treatment of nocturnal oxygen therapy in patients with mild to moderate COPD and arterial desaturation at night. Survival data was also aggregated from two trials of continuous oxygen therapy versus no oxygen therapy in mild to moderate COPD. Data could not be aggregated for the other two trials because of differences in trial design and patient selection. Nott 1980: continuous oxygen therapy versus nocturnal oxygen therapy: there was a significant improvement in mortality after 24 months (Peto odds ratio 0.45, 95% confidence interval 0.25 to 0.81). MRC 1981: domiciliary oxygen therapy versus no oxygen therapy: there was a significant improvement over five years in mortality in the group receiving oxygen therapy (Peto odds ratio 0.42, 95% confidence interval 0.18 to 0.98). In the two studies of nocturnal oxygen versus no oxygen therapy in patients with COPD and arterial desaturation at night: there was no difference in mortality between treated and non treated groups for either trial or when the trials were aggregated. In the two trials of long-term oxygen therapy versus no oxygen therapy in COPD patients with mild to moderate hypoxaemia: there was no effect on survival for up to three years of follow up.
AUTHORS' CONCLUSIONS: Long-term home oxygen therapy improved survival in a selected group of COPD patients with severe hypoxaemia (arterial PaO2 less than 55 mm Hg (8.0 kPa)). Home oxygen therapy did not appear to improve survival in patients with mild to moderate hypoxaemia or in those with only arterial desaturation at night.
J M Cranston; A J Crockett; J R Moss; J H Alpers
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2005-10-19
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-19     Completed Date:  2006-02-24     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD001744     Citation Subset:  IM    
Flinders Medical Centre, Respiratory Unit, Bedford Park, South Australia, Australia 5042.
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MeSH Terms
Anoxia / therapy
Home Care Services*
Oxygen Inhalation Therapy*
Pulmonary Disease, Chronic Obstructive / therapy*
Randomized Controlled Trials as Topic
Self Care
Update Of:
Cochrane Database Syst Rev. 2000;(4):CD001744   [PMID:  11034726 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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