| Domestic animals as reservoirs for sleeping sickness in three endemic foci in south-eastern Uganda. | |
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MedLine Citation:
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PMID: 12803870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The persistence of sleeping sickness (human African trypanosomiasis) in some areas of south-eastern Uganda has necessitated further investigations, focusing mainly on domestic animals as reservoirs of this disease in three agro-ecological zones. The inter-zone differences in the prevalences of trypanosome infection among cattle (P < 0.001) and pigs (P < 0.001) were significant. Overall, 5.0% of the cattle, 13.9% of the pigs and 0.4% of the small ruminants investigated were found to be infected with parasites of the Trypanosoma brucei subgroup. The results of blood incubation infectivity tests (BIIT) indicated that all of the T. brucei-subgroup isolates from cattle in Kamuli district (zone I) were human-serum-sensitive. Of the zone-I pigs found infected, however, almost all (82.5%) were considered to be infected with T. brucei and many (30.2%) carried human-serum-resistant T. brucei. Pig-tsetse-human appears to be a major transmission cycle in zone I. In Mukono district (zone II), 10.5% and 26.1% of the T. brucei isolates from cattle and pigs, respectively, were human-serum-resistant, indicating that cattle-tsetse-human and pig-tsetse-human are major transmission cycles in zone II. In Tororo district (zone III), 47.3% of the T. brucei isolates from cattle were human-serum-resistant but there were no T. brucei isolates from pigs, indicating that cattle-tsetse-human is the major transmission cycle. Interestingly, as the only T. brucei isolate from sheep in zone III was human-serum-resistant, there may also be a sheep-tsetse-human cycle. In south-eastern Uganda, control efforts must be designed to eliminate the parasites not only from cattle but also from pigs and small ruminants. |
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Authors:
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C Waiswa; W Olaho-Mukani; E Katunguka-Rwakishaya |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of tropical medicine and parasitology Volume: 97 ISSN: 0003-4983 ISO Abbreviation: Ann Trop Med Parasitol Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-06-13 Completed Date: 2003-07-03 Revised Date: 2009-05-18 |
Medline Journal Info:
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Nlm Unique ID: 2985178R Medline TA: Ann Trop Med Parasitol Country: England |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: IM |
Affiliation:
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Faculty of Veterinary Medicine, Makerere University, P.O. Box 7062, Kampala, Uganda. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Domestic / parasitology* Cattle Disease Reservoirs* Dog Diseases / parasitology Dogs Goat Diseases / parasitology Goats Humans Prevalence Sheep Sheep Diseases / parasitology Swine Swine Diseases / parasitology Trypanosoma brucei brucei / immunology, isolation & purification Trypanosomiasis, African / epidemiology, immunology, transmission* Trypanosomiasis, Bovine / parasitology Uganda / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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