Document Detail

Domestic animals as reservoirs for sleeping sickness in three endemic foci in south-eastern Uganda.
MedLine Citation:
PMID:  12803870     Owner:  NLM     Status:  MEDLINE    
The persistence of sleeping sickness (human African trypanosomiasis) in some areas of south-eastern Uganda has necessitated further investigations, focusing mainly on domestic animals as reservoirs of this disease in three agro-ecological zones. The inter-zone differences in the prevalences of trypanosome infection among cattle (P < 0.001) and pigs (P < 0.001) were significant. Overall, 5.0% of the cattle, 13.9% of the pigs and 0.4% of the small ruminants investigated were found to be infected with parasites of the Trypanosoma brucei subgroup. The results of blood incubation infectivity tests (BIIT) indicated that all of the T. brucei-subgroup isolates from cattle in Kamuli district (zone I) were human-serum-sensitive. Of the zone-I pigs found infected, however, almost all (82.5%) were considered to be infected with T. brucei and many (30.2%) carried human-serum-resistant T. brucei. Pig-tsetse-human appears to be a major transmission cycle in zone I. In Mukono district (zone II), 10.5% and 26.1% of the T. brucei isolates from cattle and pigs, respectively, were human-serum-resistant, indicating that cattle-tsetse-human and pig-tsetse-human are major transmission cycles in zone II. In Tororo district (zone III), 47.3% of the T. brucei isolates from cattle were human-serum-resistant but there were no T. brucei isolates from pigs, indicating that cattle-tsetse-human is the major transmission cycle. Interestingly, as the only T. brucei isolate from sheep in zone III was human-serum-resistant, there may also be a sheep-tsetse-human cycle. In south-eastern Uganda, control efforts must be designed to eliminate the parasites not only from cattle but also from pigs and small ruminants.
C Waiswa; W Olaho-Mukani; E Katunguka-Rwakishaya
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of tropical medicine and parasitology     Volume:  97     ISSN:  0003-4983     ISO Abbreviation:  Ann Trop Med Parasitol     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-06-13     Completed Date:  2003-07-03     Revised Date:  2009-05-18    
Medline Journal Info:
Nlm Unique ID:  2985178R     Medline TA:  Ann Trop Med Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Faculty of Veterinary Medicine, Makerere University, P.O. Box 7062, Kampala, Uganda.
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MeSH Terms
Animals, Domestic / parasitology*
Disease Reservoirs*
Dog Diseases / parasitology
Goat Diseases / parasitology
Sheep Diseases / parasitology
Swine Diseases / parasitology
Trypanosoma brucei brucei / immunology,  isolation & purification
Trypanosomiasis, African / epidemiology,  immunology,  transmission*
Trypanosomiasis, Bovine / parasitology
Uganda / epidemiology

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