Document Detail

Dolichol deposition in developing mammalian brain: content of free and fatty-acylated dolichol and proportion of specific isoprenologues.
MedLine Citation:
PMID:  6467016     Owner:  NLM     Status:  MEDLINE    
Dolichol serves a critical role in N-linked glycoprotein synthesis as the carrier of saccharide moieties. In this study the deposition of dolichol was investigated in developing rat brain. The contents of both the free and fatty-acylated forms of dolichol as well as the specific isoprenologues of dolichol were determined. Two distinctive phases of rapid dolichol deposition were observed; the first during brain development, and the second, with aging. The predominant form of brain dolichol was shown to be the free derivative at all ages; however, during the two phases of rapid deposition of total dolichol, fatty-acylated dolichol became detectable and increased transiently. The rapid rate of increase of brain dolichol during development occurred later than that of brain cholesterol, which shares a common biosynthetic pathway with dolichol. Thus, the peak rate of increase of dolichol occurred at 25 days postnatal, and of cholesterol, at 18 days postnatal. A distinct ontogenetic alteration in the proportion of the individual molecular species (isoprenologues) of dolichol also was defined. These observations suggest that dolichol is particularly involved in developmental events of the third to sixth postnatal weeks in rat brain, e.g. myelination and synaptogenesis.
Y Sakakihara; J J Volpe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  316     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-10-24     Completed Date:  1984-10-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  255-62     Citation Subset:  IM    
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MeSH Terms
Age Factors
Brain / metabolism*
Brain Chemistry
Cholesterol / analysis
Chromatography, High Pressure Liquid
Diterpenes / metabolism*
Dolichol / analysis,  metabolism*
Fatty Acids / analysis*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Diterpenes; 0/Fatty Acids; 2067-66-5/Dolichol; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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