| Dokhwaljihwang-tang inhibits LPS-induced inflammatory cytokine production in peripheral blood mononuclear cells. | |
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MedLine Citation:
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PMID: 20034445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Dokhwaljihwang-tang, one of the prescriptions in Four Constitution medicine, has been used to treat neurological disorders. This work was aimed to examine the effect of Dokhwaljihwang-tang on lipopolysaccharide-induced inflammatory cytokine production in peripheral blood mononuclear cells from the lesser yang subjects. METHODS: The inflammatory cytokines, interleukin 1 beta, interleukin 4 and tumor necrosis factor were measured using the ELISA. The interleukin 1 beta mRNA expression was evaluated with reverse transcriptase-polymerase chain reaction. The expression level of nuclear factor kappa B was examined by western blotting. RESULTS: Dokhwaljihwang-tang significantly inhibited interleukin 1 beta and interleukin 4 production (p<0.05). When Dokhwaljihwang-tang was pre-treated at the dose of 1 mg/ml, it not only decreased the interleukin 1 beta mRNA expression, but also inhibited the activation of nuclear factor kappa B. DISCUSSION: These results suggest the potential of Dokhwaljihwang-tang as a source of pharmaceutical acupuncture for neuronal inflammatory diseases. |
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Authors:
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Phil-Dong Moon; Na-Ra Han; Seong-Gum Ko; Hyun-Ja Jeong; Su-Jin Kim; Bo-Ra Lee; Na-Hyung Kim; In-Young Choi; Hyo-Jin An; Noh-Yil Myung; Hyejung Lee; Myong-Jo Kim; Ju-Sung Kim; Seung-Heon Hong; Hyung-Min Kim; Jae-Young Um |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurological research Volume: 32 Suppl 1 ISSN: 1743-1328 ISO Abbreviation: Neurol. Res. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2009-12-25 Completed Date: 2010-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 48-52 Citation Subset: IM |
Affiliation:
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Oriental Medical Science Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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administration & dosage,
pharmacology* Blotting, Western Cytokines / metabolism* Dose-Response Relationship, Drug Drugs, Chinese Herbal / administration & dosage, pharmacology* Enzyme-Linked Immunosorbent Assay Humans Interleukin-1beta / metabolism Interleukin-4 / metabolism Leukocytes, Mononuclear / drug effects*, metabolism Lipopolysaccharides / toxicity Medicine, Korean Traditional NF-kappa B / metabolism RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Cytokines; 0/Drugs, Chinese Herbal; 0/Interleukin-1beta; 0/Lipopolysaccharides; 0/NF-kappa B; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 0/dokhwaljihwang-tang; 207137-56-2/Interleukin-4 |
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