Document Detail


Does wave reflection dominate age-related change in aortic blood pressure across the human life span?
MedLine Citation:
PMID:  19380614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aortic systolic and pulse pressure rise with age because of aortic stiffening. Two factors are responsible: a larger incident wave because of increased aortic characteristic impedance and premature return of wave reflection from peripheral sites. This study aimed to determine the relative contribution of each factor before and after age 60 years. Aortic pressure waveforms were generated for 3682 healthy subjects using a generalized transfer function applied to radial pressure waveforms recorded by applanation tonometry. Linear regression and product of coefficient mediation analysis were performed in the cross-sectional cohort to determine the yearly contribution of the incident and reflected waves (waves measured as first systolic peak and augmented pressure, respectively) to aortic systolic and pulse pressure elevation with age. This was done separately for subjects <or=60 and >60 years of age, with both sexes initially pooled and subsequently separated. Analyses were repeated with correction for height, weight, heart rate, and mean arterial pressure. Before age 60 years, the reflected wave was a greater (P<0.05) contributor to age-related aortic systolic and pulse pressure elevations, with no significant contribution of the incident wave in this age group in sex-pooled analysis. After age 60 years, both incident and reflected waves were significant (P<0.05) and comparable contributors (P difference >0.05) to age-related aortic systolic and pulse pressure elevations. This general pattern was observed in both sexes and persisted after correction for confounders. Wave reflection is important across the life span, whereas aortic characteristic impedance contributes significantly only beyond age 60 years.
Authors:
Mayooran Namasivayam; Barry J McDonnell; Carmel M McEniery; Michael F O'Rourke;
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-20
Journal Detail:
Title:  Hypertension     Volume:  53     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  979-85     Citation Subset:  IM    
Affiliation:
St Vincent's Clinic, Victor Chang Cardiac Research Institute and University of New South Wales, Sydney, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aging / physiology*
Aorta / physiopathology*
Blood Pressure / physiology*
Cohort Studies
Confidence Intervals
Elasticity
Female
Heart Function Tests
Hemodynamics*
Humans
Hypertension / physiopathology
Male
Middle Aged
Probability
Pulsatile Flow / physiology*
Reference Values
Risk Factors
Sensitivity and Specificity
Sex Factors
Grant Support
ID/Acronym/Agency:
//Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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